About: Bilateral changes of TNF-alpha and IL-10 protein in the lumbar and cervical dorsal root ganglia following a unilateral chronic constriction injury of the sciatic nerve

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About: Bilateral changes of TNF-alpha and IL-10 protein in the lumbar and cervical dorsal root ganglia following a unilateral chronic constriction injury of the sciatic nerve Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	There is a growing evidence that cytokines act as crucial signaling molecules for response of peripheral nerves to injury. We studied levels of tumor necrosis factor alpha (TNF-a) and interleukin 10 (IL-10) proteins using ELISA in the ipsi- and contralateral lumbar and cervical dorsal root ganglia (DRG) from naive rats, rats operated for unilateral chronic constriction injury (CCI) of the sciatic nerve, and sham-operated rats. The ipsilateral hind paws of all operated rats displayed decreased withdrawal thresholds for mechanical allodynia and thermal hyperalgesia, while no significant changes were found in the contralateral hind paws and both forepaws. Bilateral elevation of TNF-a and IL-10 protein was induced in both the lumbar and cervical DRG not only in the homonymous DRG but also in the DRG unassociated with the injured nerve. There is a growing evidence that cytokines act as crucial signaling molecules for response of peripheral nerves to injury. We studied levels of tumor necrosis factor alpha (TNF-a) and interleukin 10 (IL-10) proteins using ELISA in the ipsi- and contralateral lumbar and cervical dorsal root ganglia (DRG) from naive rats, rats operated for unilateral chronic constriction injury (CCI) of the sciatic nerve, and sham-operated rats. The ipsilateral hind paws of all operated rats displayed decreased withdrawal thresholds for mechanical allodynia and thermal hyperalgesia, while no significant changes were found in the contralateral hind paws and both forepaws. Bilateral elevation of TNF-a and IL-10 protein was induced in both the lumbar and cervical DRG not only in the homonymous DRG but also in the DRG unassociated with the injured nerve. (en)
Title	Bilateral changes of TNF-alpha and IL-10 protein in the lumbar and cervical dorsal root ganglia following a unilateral chronic constriction injury of the sciatic nerve Bilateral changes of TNF-alpha and IL-10 protein in the lumbar and cervical dorsal root ganglia following a unilateral chronic constriction injury of the sciatic nerve (en)
skos:prefLabel	Bilateral changes of TNF-alpha and IL-10 protein in the lumbar and cervical dorsal root ganglia following a unilateral chronic constriction injury of the sciatic nerve Bilateral changes of TNF-alpha and IL-10 protein in the lumbar and cervical dorsal root ganglia following a unilateral chronic constriction injury of the sciatic nerve (en)
skos:notation	RIV/00216224:14110/10:00043491!RIV11-GA0-14110___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA309/07/0121), Z(MSM0021622404)
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Jančálek, Radim Hradilová Svíženská, Ivana Dubový, Petr Klusáková, Ilona
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Lékařská fakulta
http://linked.open...dnocenehoVysledku	248784
http://linked.open...ai/riv/idVysledku	RIV/00216224:14110/10:00043491
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	cytokines; tumor necrosis factor alpha; interleukin 10; behavioral tests; ELISA immunoassay; bilateral changes; neuroinflammation (en)
http://linked.open.../riv/klicoveSlovo	tumor necrosis factor alpha neuroinflammation cytokines ELISA immunoassay bilateral changes interleukin 10 behavioral tests
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[E9C78B7A4D0A]
http://linked.open...i/riv/nazevZdroje	Journal of neuroinflammation
http://linked.open...in/vavai/riv/obor	FH
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	Spatio-temporal changes of cytokines in the dorsal root ganglia of experimental neuropathic pain models induced by unilateral nerve injury
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	7/2010
http://linked.open...iv/tvurceVysledku	Dubový, Petr Hradilová Svíženská, Ivana Jančálek, Radim Klusáková, Ilona
http://linked.open...ain/vavai/riv/wos	000274831200001
http://linked.open...n/vavai/riv/zamer	The Internal Organisation and Neurobiological Mechanisms of Functional CNS Systems under Normal and Pathological Conditions
issn	1742-2094
number of pages	9 (xsd:int)
http://localhost/t...ganizacniJednotka	14110

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