About: Pharmaceutical importance of zinc and metallothionein in cell signaling.

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About: Pharmaceutical importance of zinc and metallothionein in cell signaling. Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Zinc as an essential element plays the crucial role in many physiological, but also pathological processes - zinc controls cell proliferation, differentiation, and viability including the apoptosis. These facts are especially based on the structural role of zinc ions in many proteins including the transcription factors. Due to the role of zinc in many crucial physiological processes, its homeostasis must be intensively controlled. The controlling mechanisms are based especially on the zinc transporters and low-molecular proteins metallothioneins (MTs) of the molecular weight between 6 and 10 kDa, which were firstly discovered in a horse kidneys as the cadmium binding protein. High affinity of metallothioneins to the zinc ions indicates their significant participation in the physiological, but also pathological processes, which are controlled by zinc. This paper summarizes the connection between metallothioneins and zinc and its significance on the molecular basis. Zinc as an essential element plays the crucial role in many physiological, but also pathological processes - zinc controls cell proliferation, differentiation, and viability including the apoptosis. These facts are especially based on the structural role of zinc ions in many proteins including the transcription factors. Due to the role of zinc in many crucial physiological processes, its homeostasis must be intensively controlled. The controlling mechanisms are based especially on the zinc transporters and low-molecular proteins metallothioneins (MTs) of the molecular weight between 6 and 10 kDa, which were firstly discovered in a horse kidneys as the cadmium binding protein. High affinity of metallothioneins to the zinc ions indicates their significant participation in the physiological, but also pathological processes, which are controlled by zinc. This paper summarizes the connection between metallothioneins and zinc and its significance on the molecular basis. (en)
Title	Pharmaceutical importance of zinc and metallothionein in cell signaling. Pharmaceutical importance of zinc and metallothionein in cell signaling. (en)
skos:prefLabel	Pharmaceutical importance of zinc and metallothionein in cell signaling. Pharmaceutical importance of zinc and metallothionein in cell signaling. (en)
skos:notation	RIV/00216224:14110/10:00040866!RIV11-MZ0-14110___
http://linked.open...avai/riv/aktivita	P S V
http://linked.open...avai/riv/aktivity	P(NS10200), S, V
http://linked.open...iv/cisloPeriodika	6
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Babula, Petr Kohoutková, Veronika Kizek, René Opatřilová, R.
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Lékařská fakulta
http://linked.open...dnocenehoVysledku	278706
http://linked.open...ai/riv/idVysledku	RIV/00216224:14110/10:00040866
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Metalloprotein; Metal; Transporter; Pathogenesis; Cancer (en)
http://linked.open.../riv/klicoveSlovo	Cancer Pathogenesis Metal Metalloprotein Transporter
http://linked.open...odStatuVydavatele	IT - Italská republika
http://linked.open...ontrolniKodProRIV	[471C66D86B0B]
http://linked.open...i/riv/nazevZdroje	Chimica Oggi/Chemistry today
http://linked.open...in/vavai/riv/obor	FR
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...vavai/riv/projekt	Tumor markers, their determination and correlation with prostate carcinoma
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	28
http://linked.open...iv/tvurceVysledku	Babula, Petr Kizek, René Masařík, Michal Opatřilová, Radka Daňková, Ivana Kohoutková, Veronika
issn	0392-839X
number of pages	4 (xsd:int)
http://localhost/t...ganizacniJednotka	14110

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