About: The production of mannan-binding lectin is dependent upon thyroid hormones regardless of the genotype: A cohort study of 95 patients with autoimmune thyroid disorders

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About: The production of mannan-binding lectin is dependent upon thyroid hormones regardless of the genotype: A cohort study of 95 patients with autoimmune thyroid disorders Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Serum levels of MBL and parameters of the thyroid function were determined in 62 patients with Hashimoto's thyroiditis, 33 with Graves' disease and 47 blood donors. Follow-up measurements were performed after 6 to 24 months. MBL2 genotypes were determined using multiplex PCR and compared to 359 healthy Czech individuals. Serum levels of MBL tightly correlated with thyroid hormones, leading to strongly increased MBL levels in hyperthyroidism and decreased levels in hypothyroidism. With normalization of the thyroid function during follow-up, MBL levels decreased or increased respectively. The observed correlations were not due to MBL polymorphisms since the frequency of MBL2 polymorphisms in AITD patients was not different from the general population. We conclude that AITD are not associated with MBL polymorphisms. However, the MBL production is strongly dependent on thyroid function, regardless of the genotype. Serum levels of MBL and parameters of the thyroid function were determined in 62 patients with Hashimoto's thyroiditis, 33 with Graves' disease and 47 blood donors. Follow-up measurements were performed after 6 to 24 months. MBL2 genotypes were determined using multiplex PCR and compared to 359 healthy Czech individuals. Serum levels of MBL tightly correlated with thyroid hormones, leading to strongly increased MBL levels in hyperthyroidism and decreased levels in hypothyroidism. With normalization of the thyroid function during follow-up, MBL levels decreased or increased respectively. The observed correlations were not due to MBL polymorphisms since the frequency of MBL2 polymorphisms in AITD patients was not different from the general population. We conclude that AITD are not associated with MBL polymorphisms. However, the MBL production is strongly dependent on thyroid function, regardless of the genotype. (en)
Title	The production of mannan-binding lectin is dependent upon thyroid hormones regardless of the genotype: A cohort study of 95 patients with autoimmune thyroid disorders The production of mannan-binding lectin is dependent upon thyroid hormones regardless of the genotype: A cohort study of 95 patients with autoimmune thyroid disorders (en)
skos:prefLabel	The production of mannan-binding lectin is dependent upon thyroid hormones regardless of the genotype: A cohort study of 95 patients with autoimmune thyroid disorders The production of mannan-binding lectin is dependent upon thyroid hormones regardless of the genotype: A cohort study of 95 patients with autoimmune thyroid disorders (en)
skos:notation	RIV/00216224:14110/10:00040792!RIV11-MZ0-14110___
http://linked.open...avai/riv/aktivita	I P
http://linked.open...avai/riv/aktivity	I, P(NS10662)
http://linked.open...iv/cisloPeriodika	136
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Grodecká, Lucie Freiberger, Tomáš
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Lékařská fakulta
http://linked.open...dnocenehoVysledku	282483
http://linked.open...ai/riv/idVysledku	RIV/00216224:14110/10:00040792
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Mannan-binding lectin; Complement; Autoimmune thyroid disorders; Graves' disease; Hashimoto's thyroiditis (en)
http://linked.open.../riv/klicoveSlovo	Mannan-binding lectin Autoimmune thyroid disorders Complement Graves' disease Hashimoto's thyroiditis
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[3BF9188BE46A]
http://linked.open...i/riv/nazevZdroje	CLINICAL IMMUNOLOGY
http://linked.open...in/vavai/riv/obor	EC
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	12 (xsd:int)
http://linked.open...vavai/riv/projekt	Complement in the pathogenesis of autoimmune thyroid disorders
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	roč. 2010
http://linked.open...iv/tvurceVysledku	Freiberger, Tomáš Jiskra, Jan Trendelenburg, Marten Grodecká, Lucie Antosova, Marie Limanova, Zdenka Malickova, Karin Potlukova, Eliška Sinikka Pesickova, Satu Springer, Drahomira Telicka, Zdenek Zivorova, Dana
http://linked.open...ain/vavai/riv/wos	000278954300013
issn	1521-6616
number of pages	7 (xsd:int)
http://localhost/t...ganizacniJednotka	14110

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