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rdf:type
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Description
| - Chronic lymphocytic leukemia (CLL) is the most common leukemia in the western world and is characterized by a highly variable clinical course. CLL can be classified into two biological subtypes, according to the presence or absence of somatic mutations in the immunoglobulin heavy-chain variable region (IgVH). IgVH mutational status is of high-clinical relevance: cases with unmutated IgVH show a less favorable course with a rapid progression, whereas cases with mutated IgVH show a stable disease and longer survival. Unfavorable prognosis is also associated with the inactivation of an important tumor-suppressor p53; these patients harbor a deletion of 17p13 and this chromosomal abnormality is often accompanied by the mutation of the second TP53 allele, which leads to the complete elimination of p53 function. Moreover, a single mutation of one of the TP53 allele also occurs in a significant proportion of CLL cases.
- Chronic lymphocytic leukemia (CLL) is the most common leukemia in the western world and is characterized by a highly variable clinical course. CLL can be classified into two biological subtypes, according to the presence or absence of somatic mutations in the immunoglobulin heavy-chain variable region (IgVH). IgVH mutational status is of high-clinical relevance: cases with unmutated IgVH show a less favorable course with a rapid progression, whereas cases with mutated IgVH show a stable disease and longer survival. Unfavorable prognosis is also associated with the inactivation of an important tumor-suppressor p53; these patients harbor a deletion of 17p13 and this chromosomal abnormality is often accompanied by the mutation of the second TP53 allele, which leads to the complete elimination of p53 function. Moreover, a single mutation of one of the TP53 allele also occurs in a significant proportion of CLL cases. (en)
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Title
| - miR-34a, miR-29c and miR-17-5p are downregulated in CLL patients with TP53 abnormalities
- miR-34a, miR-29c and miR-17-5p are downregulated in CLL patients with TP53 abnormalities (en)
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skos:prefLabel
| - miR-34a, miR-29c and miR-17-5p are downregulated in CLL patients with TP53 abnormalities
- miR-34a, miR-29c and miR-17-5p are downregulated in CLL patients with TP53 abnormalities (en)
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skos:notation
| - RIV/00216224:14110/09:00067111!RIV14-MSM-14110___
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
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http://linked.open...iv/cisloPeriodika
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
| - Mráz, Marek
- Kotašková, Jana
- Pospíšilová, Šárka
- Brychtová, Yvona
- Doubek, Michael
- Mayer, Jiří
- Tichý, Boris
- Stano Kozubík, Kateřina
- Pavlová, Šárka
- Malčíková, Jitka
- Trbušek, Martin
- Plevová, Karla
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/00216224:14110/09:00067111
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - CHRONIC LYMPHOCYTIC-LEUKEMIA; EXPRESSION; MICRORNAS (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...odStatuVydavatele
| - GB - Spojené království Velké Británie a Severního Irska
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http://linked.open...ontrolniKodProRIV
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http://linked.open...i/riv/nazevZdroje
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...vavai/riv/projekt
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http://linked.open...UplatneniVysledku
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http://linked.open...v/svazekPeriodika
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http://linked.open...iv/tvurceVysledku
| - Brychtová, Yvona
- Doubek, Michael
- Mayer, Jiří
- Mráz, Marek
- Pospíšilová, Šárka
- Tichý, Boris
- Pavlová, Šárka
- Malčíková, Jitka
- Trbušek, Martin
- Šmardová, Jana
- Staňo Kozubík, Kateřina
- Kotašková, Jana
- Malinová, Karla
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http://linked.open...ain/vavai/riv/wos
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issn
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number of pages
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http://bibframe.org/vocab/doi
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http://localhost/t...ganizacniJednotka
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