About: miR-34a, miR-29c and miR-17-5p are downregulated in CLL patients with TP53 abnormalities

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About: miR-34a, miR-29c and miR-17-5p are downregulated in CLL patients with TP53 abnormalities Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Chronic lymphocytic leukemia (CLL) is the most common leukemia in the western world and is characterized by a highly variable clinical course. CLL can be classified into two biological subtypes, according to the presence or absence of somatic mutations in the immunoglobulin heavy-chain variable region (IgVH). IgVH mutational status is of high-clinical relevance: cases with unmutated IgVH show a less favorable course with a rapid progression, whereas cases with mutated IgVH show a stable disease and longer survival. Unfavorable prognosis is also associated with the inactivation of an important tumor-suppressor p53; these patients harbor a deletion of 17p13 and this chromosomal abnormality is often accompanied by the mutation of the second TP53 allele, which leads to the complete elimination of p53 function. Moreover, a single mutation of one of the TP53 allele also occurs in a significant proportion of CLL cases. Chronic lymphocytic leukemia (CLL) is the most common leukemia in the western world and is characterized by a highly variable clinical course. CLL can be classified into two biological subtypes, according to the presence or absence of somatic mutations in the immunoglobulin heavy-chain variable region (IgVH). IgVH mutational status is of high-clinical relevance: cases with unmutated IgVH show a less favorable course with a rapid progression, whereas cases with mutated IgVH show a stable disease and longer survival. Unfavorable prognosis is also associated with the inactivation of an important tumor-suppressor p53; these patients harbor a deletion of 17p13 and this chromosomal abnormality is often accompanied by the mutation of the second TP53 allele, which leads to the complete elimination of p53 function. Moreover, a single mutation of one of the TP53 allele also occurs in a significant proportion of CLL cases. (en)
Title	miR-34a, miR-29c and miR-17-5p are downregulated in CLL patients with TP53 abnormalities miR-34a, miR-29c and miR-17-5p are downregulated in CLL patients with TP53 abnormalities (en)
skos:prefLabel	miR-34a, miR-29c and miR-17-5p are downregulated in CLL patients with TP53 abnormalities miR-34a, miR-29c and miR-17-5p are downregulated in CLL patients with TP53 abnormalities (en)
skos:notation	RIV/00216224:14110/09:00067111!RIV14-MSM-14110___
http://linked.open...avai/riv/aktivita	I P
http://linked.open...avai/riv/aktivity	I, P(NR9293)
http://linked.open...iv/cisloPeriodika	6
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Mráz, Marek Kotašková, Jana Pospíšilová, Šárka Brychtová, Yvona Doubek, Michael Mayer, Jiří Tichý, Boris Stano Kozubík, Kateřina Pavlová, Šárka Malčíková, Jitka Trbušek, Martin Plevová, Karla
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Lékařská fakulta
http://linked.open...dnocenehoVysledku	326481
http://linked.open...ai/riv/idVysledku	RIV/00216224:14110/09:00067111
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	CHRONIC LYMPHOCYTIC-LEUKEMIA; EXPRESSION; MICRORNAS (en)
http://linked.open.../riv/klicoveSlovo	CHRONIC LYMPHOCYTIC-LEUKEMIA EXPRESSION MICRORNAS
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[DB59BA19ED34]
http://linked.open...i/riv/nazevZdroje	Leukemia
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	12 (xsd:int)
http://linked.open...cetTvurcuVysledku	13 (xsd:int)
http://linked.open...vavai/riv/projekt	Application of MicroRNAs and Small Interfering RNAs in Diagnostics and Treatment of Leukemia
http://linked.open...UplatneniVysledku	2009
http://linked.open...v/svazekPeriodika	23
http://linked.open...iv/tvurceVysledku	Brychtová, Yvona Doubek, Michael Mayer, Jiří Mráz, Marek Pospíšilová, Šárka Tichý, Boris Pavlová, Šárka Malčíková, Jitka Trbušek, Martin Šmardová, Jana Staňo Kozubík, Kateřina Kotašková, Jana Malinová, Karla
http://linked.open...ain/vavai/riv/wos	000266820700018
issn	0887-6924
number of pages	5 (xsd:int)
http://bibframe.org/vocab/doi	10.1038/leu.2008.377
http://localhost/t...ganizacniJednotka	14110

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