About: Evaluation of the activity of P450 enzymes in rats: use of the single marker or combined drug administration.

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About: Evaluation of the activity of P450 enzymes in rats: use of the single marker or combined drug administration. Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	A %22cocktail%22 of several substrates is frequently used to assess metabolic activity of multiple cytochrome P450 enzymes in one session. Some interactions among substrates can appear and may influence the rate of biotransformation of other ones. Our current work was aimed on the influence of tolbutamide on cytochrome P450-mediated metabolism of phenacetin and vice versa. In the presented work, the biotransformation rates of phenacetin and tolbutamide (markers of rat CYP1A2 and CYP2C6/11 metabolic activities, respectively) administered either separately or both simultaneously were compared. The model of isolated perfused rat liver was used. Phenacetin had no significant effect on tolbutamide hydroxylation. Tolbutamide addition to the perfusion medium significantly increased the rate of O-deethylation of phenacetin. Some differences in the rate of P450-mediated metabolism can be observed when comparing assessment using combination of two model substrates with the common way (single marker administration). A %22cocktail%22 of several substrates is frequently used to assess metabolic activity of multiple cytochrome P450 enzymes in one session. Some interactions among substrates can appear and may influence the rate of biotransformation of other ones. Our current work was aimed on the influence of tolbutamide on cytochrome P450-mediated metabolism of phenacetin and vice versa. In the presented work, the biotransformation rates of phenacetin and tolbutamide (markers of rat CYP1A2 and CYP2C6/11 metabolic activities, respectively) administered either separately or both simultaneously were compared. The model of isolated perfused rat liver was used. Phenacetin had no significant effect on tolbutamide hydroxylation. Tolbutamide addition to the perfusion medium significantly increased the rate of O-deethylation of phenacetin. Some differences in the rate of P450-mediated metabolism can be observed when comparing assessment using combination of two model substrates with the common way (single marker administration). (en)
Title	Evaluation of the activity of P450 enzymes in rats: use of the single marker or combined drug administration. Evaluation of the activity of P450 enzymes in rats: use of the single marker or combined drug administration. (en)
skos:prefLabel	Evaluation of the activity of P450 enzymes in rats: use of the single marker or combined drug administration. Evaluation of the activity of P450 enzymes in rats: use of the single marker or combined drug administration. (en)
skos:notation	RIV/00216224:14110/09:00038331!RIV10-MSM-14110___
http://linked.open...avai/riv/aktivita	P S Z
http://linked.open...avai/riv/aktivity	P(LC06023), S, Z(MSM0021622404)
http://linked.open...iv/cisloPeriodika	30
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Kýr, Michal Juřica, Jan Tomandl, Josef McCaskey Hadašová, Eva
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Lékařská fakulta
http://linked.open...dnocenehoVysledku	313924
http://linked.open...ai/riv/idVysledku	RIV/00216224:14110/09:00038331
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	P450; rat; metabolic activity; evaluation; marker combination (en)
http://linked.open.../riv/klicoveSlovo	P450 evaluation rat metabolic activity marker combination
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[E4417554E43A]
http://linked.open...i/riv/nazevZdroje	Neuroendocrinology Letters
http://linked.open...in/vavai/riv/obor	FR
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	Integrated bioanalytical technologies for microanalyses and diagnostics with laser induced fluorescence and mass spectrometry coupling.
http://linked.open...UplatneniVysledku	2009
http://linked.open...v/svazekPeriodika	2009
http://linked.open...iv/tvurceVysledku	Juřica, Jan Tomandl, Josef Kýr, Michal McCaskey Hadašová, Eva
http://linked.open...n/vavai/riv/zamer	The Internal Organisation and Neurobiological Mechanisms of Functional CNS Systems under Normal and Pathological Conditions
issn	0172-780X
number of pages	4 (xsd:int)
http://localhost/t...ganizacniJednotka	14110

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