About: Bone marrow versus peripheral blood: comparison of the chimerism analysis

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Background Bone marrow (BM) examination is routinely performed for minimal residual disease monitoring in leukemia patients. By contrast, chimerism is usually tested from peripheral blood (PB), and, surprisingly, little is known about the clinical impact of the chimerism status in BM. Patients and Methods 226 pairs of PB and BM samples obtained from 102 adult patients were investigated. Frequencies of diagnoses within samples were as follows: AML 42%, CML 24%, ALL 11%, CLL 7%, MDS 7%, other hematological malignancies 9%. Assessment of chimerism was performed using either capillary electrophoresis with fluorescence detection, or quantitative real-time PCR with one order of magnitude higher sensitivity of mixed chimerism detection. Results Mixed chimerism in BM was detected even more than 9 years after transplantation, however, on the other hand, complete donor chimerism was also observed as early as day +35. Background Bone marrow (BM) examination is routinely performed for minimal residual disease monitoring in leukemia patients. By contrast, chimerism is usually tested from peripheral blood (PB), and, surprisingly, little is known about the clinical impact of the chimerism status in BM. Patients and Methods 226 pairs of PB and BM samples obtained from 102 adult patients were investigated. Frequencies of diagnoses within samples were as follows: AML 42%, CML 24%, ALL 11%, CLL 7%, MDS 7%, other hematological malignancies 9%. Assessment of chimerism was performed using either capillary electrophoresis with fluorescence detection, or quantitative real-time PCR with one order of magnitude higher sensitivity of mixed chimerism detection. Results Mixed chimerism in BM was detected even more than 9 years after transplantation, however, on the other hand, complete donor chimerism was also observed as early as day +35. (en)
Title	Bone marrow versus peripheral blood: comparison of the chimerism analysis Bone marrow versus peripheral blood: comparison of the chimerism analysis (en)
skos:prefLabel	Bone marrow versus peripheral blood: comparison of the chimerism analysis Bone marrow versus peripheral blood: comparison of the chimerism analysis (en)
skos:notation	RIV/00216224:14110/09:00036469!RIV10-MSM-14110___
http://linked.open...avai/riv/aktivita	Z
http://linked.open...avai/riv/aktivity	Z(MSM0021622430)
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Horký, Ondřej Dvořáková, Dana Brychtová, Yvona Mayer, Jiří Krejčí, Marta
http://linked.open.../riv/druhVysledku	O - Ostatní výsledky nezařaditelné do žádného z výše uvedených druhů výsledku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Lékařská fakulta
http://linked.open...dnocenehoVysledku	305407
http://linked.open...ai/riv/idVysledku	RIV/00216224:14110/09:00036469
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	chimerism; bone marrow; peripheral blood (en)
http://linked.open.../riv/klicoveSlovo	chimerism peripheral blood bone marrow
http://linked.open...ontrolniKodProRIV	[D6ED3B84E912]
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	5 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...UplatneniVysledku	2009
http://linked.open...iv/tvurceVysledku	Brychtová, Yvona Dvořáková, Dana Horký, Ondřej Krejčí, Marta Mayer, Jiří Kablásková, Lenka
http://linked.open...n/vavai/riv/zamer	Functional and molecular characteristics of cancer and normal stem cells - identification of targets for novel therapeutics and therapeutic strategies
http://localhost/t...ganizacniJednotka	14110

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