About: CEBPA Gene mutational status A complete screening using high-resolution melt curve analysis

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	In recent years, several independent prognostic factors in cytogenetically normal acute myeloid leukemia (CN-AML) have been reported. Mutations or the expression levels of certatin genes have been often used as molecular markers for preidiction of a patients outcome or for evaluation of treatment outcome. One of them, the gene encoding CCAAT/enhanced binding protein alpha (CEBPA), plays an important role in myeloid differentiation and, whn mutated, confers a favorable prognosis for patients with CN-AML. Complete mutation screening of the CEBPA gene is therefore beneficial and requires fast, precise, and sensitive diagnostic tools. Thus, for routine diagnostics, we developed a screening method using high-resolution melt curve analysis prior to direct sequencing, where only positive samples (according to reference) are further sequenced. In recent years, several independent prognostic factors in cytogenetically normal acute myeloid leukemia (CN-AML) have been reported. Mutations or the expression levels of certatin genes have been often used as molecular markers for preidiction of a patients outcome or for evaluation of treatment outcome. One of them, the gene encoding CCAAT/enhanced binding protein alpha (CEBPA), plays an important role in myeloid differentiation and, whn mutated, confers a favorable prognosis for patients with CN-AML. Complete mutation screening of the CEBPA gene is therefore beneficial and requires fast, precise, and sensitive diagnostic tools. Thus, for routine diagnostics, we developed a screening method using high-resolution melt curve analysis prior to direct sequencing, where only positive samples (according to reference) are further sequenced. (en)
Title	CEBPA Gene mutational status A complete screening using high-resolution melt curve analysis CEBPA Gene mutational status A complete screening using high-resolution melt curve analysis (en)
skos:prefLabel	CEBPA Gene mutational status A complete screening using high-resolution melt curve analysis CEBPA Gene mutational status A complete screening using high-resolution melt curve analysis (en)
skos:notation	RIV/00216224:14110/09:00036369!RIV11-MSM-14110___
http://linked.open...avai/riv/aktivita	V Z
http://linked.open...avai/riv/aktivity	V, Z(MSM0021622430)
http://linked.open...iv/cisloPeriodika	3
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Rázga, Filip Dvořáková, Dana Mayer, Jiří Jurček, Tomáš
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Lékařská fakulta
http://linked.open...dnocenehoVysledku	306192
http://linked.open...ai/riv/idVysledku	RIV/00216224:14110/09:00036369
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	acute myeloid leukemia; CEBPA mutation (en)
http://linked.open.../riv/klicoveSlovo	acute myeloid leukemia CEBPA mutation
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[EAB069696207]
http://linked.open...i/riv/nazevZdroje	Molecular diagnosis and therapy
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...UplatneniVysledku	2009
http://linked.open...v/svazekPeriodika	13
http://linked.open...iv/tvurceVysledku	Dvořáková, Dana Jurček, Tomáš Mayer, Jiří Rázga, Filip Ježíšková, Ivana Křístková, Zlatuše
http://linked.open...ain/vavai/riv/wos	000269290600004
http://linked.open...n/vavai/riv/zamer	Functional and molecular characteristics of cancer and normal stem cells - identification of targets for novel therapeutics and therapeutic strategies
issn	1177-1062
number of pages	6 (xsd:int)
http://localhost/t...ganizacniJednotka	14110

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