About: Dibenzocyclooctadiene lignans overcome drug resistance in lung cancer cells

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About: Dibenzocyclooctadiene lignans overcome drug resistance in lung cancer cells - Study of structure-activity relationship Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	A panel of nine dibenzo[a,c]cyclooctadiene lignans, schizandrin, gomisin A, gomisin N, gomisin J, angeloylgomisin H, tigloylgomisin P, deoxyschizandrin, gama-schizandrin and wuweizisu C was examined for their effect on multidrug resistance, as well as their anti-proliferative activities. COR-L23/R, a multidrug-resistant sub-line, which has been reported to over-express multidrug resistance-associated protein (MRP1), was used for the experiments together with its parent cell line COR-L23 (human lung cell carcinoma). We found that lignans deoxyschizandrin and gama-schizandrin at relatively non-toxic concentrations restored the cytotoxic action of doxorubicin to COR-L23/R cells. Deoxyschizandrin and gama-schizandrin also significantly enhanced the accumulation of doxorubicin in drug resistant cells. A panel of nine dibenzo[a,c]cyclooctadiene lignans, schizandrin, gomisin A, gomisin N, gomisin J, angeloylgomisin H, tigloylgomisin P, deoxyschizandrin, gama-schizandrin and wuweizisu C was examined for their effect on multidrug resistance, as well as their anti-proliferative activities. COR-L23/R, a multidrug-resistant sub-line, which has been reported to over-express multidrug resistance-associated protein (MRP1), was used for the experiments together with its parent cell line COR-L23 (human lung cell carcinoma). We found that lignans deoxyschizandrin and gama-schizandrin at relatively non-toxic concentrations restored the cytotoxic action of doxorubicin to COR-L23/R cells. Deoxyschizandrin and gama-schizandrin also significantly enhanced the accumulation of doxorubicin in drug resistant cells. (en)
Title	Dibenzocyclooctadiene lignans overcome drug resistance in lung cancer cells - Study of structure-activity relationship Dibenzocyclooctadiene lignans overcome drug resistance in lung cancer cells - Study of structure-activity relationship (en)
skos:prefLabel	Dibenzocyclooctadiene lignans overcome drug resistance in lung cancer cells - Study of structure-activity relationship Dibenzocyclooctadiene lignans overcome drug resistance in lung cancer cells - Study of structure-activity relationship (en)
skos:notation	RIV/00216224:14110/09:00029837!RIV11-GA0-14110___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA522/07/0995), P(LC06035), Z(MSM0021622415)
http://linked.open...iv/cisloPeriodika	6
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Slaninová, Iva Porubová, Ludmila Slanina, Jiří
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Lékařská fakulta
http://linked.open...dnocenehoVysledku	310267
http://linked.open...ai/riv/idVysledku	RIV/00216224:14110/09:00029837
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	COR-L23/R; cytotoxicity; doxorubicin; dibenzocyclooctadiene lignans; multidrug resistance; MRP protein (en)
http://linked.open.../riv/klicoveSlovo	cytotoxicity COR-L23/R MRP protein multidrug resistance doxorubicin dibenzocyclooctadiene lignans
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[E59F5C1DAD7D]
http://linked.open...i/riv/nazevZdroje	Toxicology in Vitro
http://linked.open...in/vavai/riv/obor	EF
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	Centre of Biophysical Chemistry, Bioelectrochemistry and Bioanalysis. New Tools for Genomics, Proteomics and Biomedicine. Regulation of secondary metabolites biosynthesis in cell culture of Schisandra chinensis
http://linked.open...UplatneniVysledku	2009
http://linked.open...v/svazekPeriodika	23
http://linked.open...iv/tvurceVysledku	Slaninová, Iva Koubíková, Ludmila Slanina, Jiří Březinová, Lenka
http://linked.open...ain/vavai/riv/wos	000269551500013
http://linked.open...n/vavai/riv/zamer	Molecular basis of cell and tissue regulations
issn	0887-2333
number of pages	8 (xsd:int)
http://localhost/t...ganizacniJednotka	14110

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