About: Resolution of action voltage of cardiac cells into components represented by transferred charges

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Action voltage of cardiac cells is expressed as a sum of particular components representing contributions of individual ionic currents in terms of electrical charges transferred across cell membrane. Biophysical models describing electrical membrane phenomena in rat and human ventricular cardiomyocytes by sets of nonlinear differential equations are used to verify the proposed approach. Computer simulations indicated that in rat model action voltage waveform is largely formed by three current components: L-type calcium current ICa, fast sodium current INa, and transient outward current IKto. In contrast, in human ventricular cell, participation of other components is much more significant. Particularly, the currents generated by electrogenic carrier mechanisms Na-Ca, Na-K and sarcolemmal Ca-pump play an important role. Action voltage of cardiac cells is expressed as a sum of particular components representing contributions of individual ionic currents in terms of electrical charges transferred across cell membrane. Biophysical models describing electrical membrane phenomena in rat and human ventricular cardiomyocytes by sets of nonlinear differential equations are used to verify the proposed approach. Computer simulations indicated that in rat model action voltage waveform is largely formed by three current components: L-type calcium current ICa, fast sodium current INa, and transient outward current IKto. In contrast, in human ventricular cell, participation of other components is much more significant. Particularly, the currents generated by electrogenic carrier mechanisms Na-Ca, Na-K and sarcolemmal Ca-pump play an important role. (en)
Title	Resolution of action voltage of cardiac cells into components represented by transferred charges Resolution of action voltage of cardiac cells into components represented by transferred charges (en)
skos:prefLabel	Resolution of action voltage of cardiac cells into components represented by transferred charges Resolution of action voltage of cardiac cells into components represented by transferred charges (en)
skos:notation	RIV/00216224:14110/08:00034480!RIV11-MSM-14110___
http://linked.open...avai/riv/aktivita	Z
http://linked.open...avai/riv/aktivity	Z(MSM0021622402)
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Pásek, Michal Šimurda, Jiří Šimurdová, Milena
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Lékařská fakulta
http://linked.open...dnocenehoVysledku	392540
http://linked.open...ai/riv/idVysledku	RIV/00216224:14110/08:00034480
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Cardiac cell; Action voltage; Resolution into components; Transferred electrical charges (en)
http://linked.open.../riv/klicoveSlovo	Cardiac cell Action voltage Resolution into components Transferred electrical charges
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[5239126F0801]
http://linked.open...i/riv/nazevZdroje	Analysis of Biomedical Signals and Images
http://linked.open...in/vavai/riv/obor	BO
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	3 (xsd:int)
http://linked.open...UplatneniVysledku	2008
http://linked.open...v/svazekPeriodika	19
http://linked.open...iv/tvurceVysledku	Pásek, Michal Šimurda, Jiří Šimurdová, Milena
http://linked.open...n/vavai/riv/zamer	Early diagnostics and treatment of cardiovascular diseases
issn	1211-412X
number of pages	4 (xsd:int)
http://localhost/t...ganizacniJednotka	14110

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