About: Obesity-related genes variability in Czech patients with sporadic colorectal cancer: preliminary results.

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About: Obesity-related genes variability in Czech patients with sporadic colorectal cancer: preliminary results. Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Genetic variability in obesity related genes and the resulting phenotypes are being recognized as major risk factors for colorectal cancer and/or severity of the disease. A total of 102 patients (79 men and 23 women) and 101 age matched individuals without colorectal cancer, 59 men and 42 women, were recruited. All the individuals were genotyped for the following subset of polymorphisms in obesity-related genes: angiotensinogen gene (M235T and 6A/G), in IL6 gene (174 G/C and 596 A/G), in leptin gene (2548 A/G), and polymorphism Gln223Arg within the leptin receptor (LEPR) gene. A significant increase in frequency of double heterozygote genotype (MTAG) of both angiotensinogen polymorphisms in males with colorectal cancer was observed when compared to control men (odds ratio (OR)=3.77, P corr=0.001). A marginally significant difference in genotype distribution of 174 G/C IL6 polymorphism between the patients in stage I,II compared to patients in III,IV was found (P g=0.05, P a=0.173). Genetic variability in obesity related genes and the resulting phenotypes are being recognized as major risk factors for colorectal cancer and/or severity of the disease. A total of 102 patients (79 men and 23 women) and 101 age matched individuals without colorectal cancer, 59 men and 42 women, were recruited. All the individuals were genotyped for the following subset of polymorphisms in obesity-related genes: angiotensinogen gene (M235T and 6A/G), in IL6 gene (174 G/C and 596 A/G), in leptin gene (2548 A/G), and polymorphism Gln223Arg within the leptin receptor (LEPR) gene. A significant increase in frequency of double heterozygote genotype (MTAG) of both angiotensinogen polymorphisms in males with colorectal cancer was observed when compared to control men (odds ratio (OR)=3.77, P corr=0.001). A marginally significant difference in genotype distribution of 174 G/C IL6 polymorphism between the patients in stage I,II compared to patients in III,IV was found (P g=0.05, P a=0.173). (en)
Title	Obesity-related genes variability in Czech patients with sporadic colorectal cancer: preliminary results. Obesity-related genes variability in Czech patients with sporadic colorectal cancer: preliminary results. (en)
skos:prefLabel	Obesity-related genes variability in Czech patients with sporadic colorectal cancer: preliminary results. Obesity-related genes variability in Czech patients with sporadic colorectal cancer: preliminary results. (en)
skos:notation	RIV/00216224:14110/08:00034463!RIV10-MSM-14110___
http://linked.open...avai/riv/aktivita	P V
http://linked.open...avai/riv/aktivity	P(KJB501620601), V
http://linked.open...iv/cisloPeriodika	XX
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Vokurka, Jiří Vašků, Anna Bienertová-Vašků, Julie
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Lékařská fakulta
http://linked.open...dnocenehoVysledku	383791
http://linked.open...ai/riv/idVysledku	RIV/00216224:14110/08:00034463
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	obesity -related genes-colorectal cancer-gene polymorphism.Angiotensinogen-il-6-Leptin-Leptin receptor (en)
http://linked.open.../riv/klicoveSlovo	obesity -related genes-colorectal cancer-gene polymorphism.Angiotensinogen-il-6-Leptin-Leptin receptor
http://linked.open...odStatuVydavatele	DE - Spolková republika Německo
http://linked.open...ontrolniKodProRIV	[954B871B29F2]
http://linked.open...i/riv/nazevZdroje	Int J Colorectal Dis
http://linked.open...in/vavai/riv/obor	FJ
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	3 (xsd:int)
http://linked.open...vavai/riv/projekt	Functional analysis of the RAGE gene susceptibility haplotype and its role in the hyperglycemia-driven pathology
http://linked.open...UplatneniVysledku	2008
http://linked.open...v/svazekPeriodika	XX
http://linked.open...iv/tvurceVysledku	Bienertová Vašků, Julie Vašků, Anna Vokurka, Jiří
http://linked.open...ain/vavai/riv/wos	000262986000006
issn	0179-1958
number of pages	6 (xsd:int)
http://localhost/t...ganizacniJednotka	14110

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