About: Is there any link between severe pre-eclampsia and defined polymorphisms in leptin and adiponectin genes?     Goto   Sponge   NotDistinct   Permalink

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  • Aim: The pathophysiology of pre-eclampsia, one of the leading causes of maternal mortality worldwide, still remains unclear. Recently, it has been suggested that impaired regulation of complex interactions among various adipokines plays an important role in the development of pre-eclampsia. The aim of this study was to investigate whether the two common polymorphisms of the leptin (LEP) and adiponectin (APM1) genes are associated with the development of pre-eclampsia and its related traits (gestational hypertension, proteinuria and various measures of reduced fetal growth) in the Czech pre-eclamptic population. Methods: The case-control study comprised a total of 123 pre-eclamptic women and 150 healthy controls of similar age and parity distribution. They were genotyped for the LEP -2548G/A (5-untranslated region) and APM1 T94G (exon 2) polymorphisms using polymerase chain reaction. Results: The allele frequency of the LEP -2548G polymorphism was 0.541 in the pre-eclamptic group versus 0.
  • Aim: The pathophysiology of pre-eclampsia, one of the leading causes of maternal mortality worldwide, still remains unclear. Recently, it has been suggested that impaired regulation of complex interactions among various adipokines plays an important role in the development of pre-eclampsia. The aim of this study was to investigate whether the two common polymorphisms of the leptin (LEP) and adiponectin (APM1) genes are associated with the development of pre-eclampsia and its related traits (gestational hypertension, proteinuria and various measures of reduced fetal growth) in the Czech pre-eclamptic population. Methods: The case-control study comprised a total of 123 pre-eclamptic women and 150 healthy controls of similar age and parity distribution. They were genotyped for the LEP -2548G/A (5-untranslated region) and APM1 T94G (exon 2) polymorphisms using polymerase chain reaction. Results: The allele frequency of the LEP -2548G polymorphism was 0.541 in the pre-eclamptic group versus 0. (en)
Title
  • Is there any link between severe pre-eclampsia and defined polymorphisms in leptin and adiponectin genes?
  • Is there any link between severe pre-eclampsia and defined polymorphisms in leptin and adiponectin genes? (en)
skos:prefLabel
  • Is there any link between severe pre-eclampsia and defined polymorphisms in leptin and adiponectin genes?
  • Is there any link between severe pre-eclampsia and defined polymorphisms in leptin and adiponectin genes? (en)
skos:notation
  • RIV/00216224:14110/08:00033484!RIV10-MSM-14110___
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • V
http://linked.open...iv/cisloPeriodika
  • XX
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 373362
http://linked.open...ai/riv/idVysledku
  • RIV/00216224:14110/08:00033484
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • adiponectin; leptin; polymorphism; preeclampsia (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • JP - Japonsko
http://linked.open...ontrolniKodProRIV
  • [C237C8818B80]
http://linked.open...i/riv/nazevZdroje
  • The Journal of Obstetrics and Gynaecology Research
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 2008
http://linked.open...iv/tvurceVysledku
  • Bienertová Vašků, Julie
  • Bienert, Petr
  • Dostálová, Zuzana
  • Unzeitig, Vít
  • Vašků, Anna
  • Kaňková, Kateřina
http://linked.open...ain/vavai/riv/wos
  • 000259270800014
issn
  • 1341-8076
number of pages
http://localhost/t...ganizacniJednotka
  • 14110
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