About: Significance of microRNA-21 in colorectal cancer pathogenesis.

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About: Significance of microRNA-21 in colorectal cancer pathogenesis. Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	MicroRNAs (miRNAs) are endogenously expressed short non-coding RNAs, that repress protein translation through binding to target mRNAs. Although the number of verified human miRNA is still expanding, only few have been functionally described. However, emerging evidences suggest the involvement of altered regulation of miRNA in pathogenesis of cancers and these genes are thought to function as both tumours suppressor and oncogenes. Previous studies, mainly based on microarrays technology applied on colorectal cancer cell lines, showed altered expression levels of several miRNAs in colorectal cancer (CRC). In our study, we examined by Real-Time PCR expression levels of microRNA-21 (miR-21) in tumors of 29 colorectal cancer patients. For 6 cases of CRC samples also adjacent non-tumor tissues were analyzed. For data normalization we tried different approaches (18S rRNA, GAPDH, let-7a-1). Finally, variability of let-7a-1 expression was shown to be the lowest. MicroRNAs (miRNAs) are endogenously expressed short non-coding RNAs, that repress protein translation through binding to target mRNAs. Although the number of verified human miRNA is still expanding, only few have been functionally described. However, emerging evidences suggest the involvement of altered regulation of miRNA in pathogenesis of cancers and these genes are thought to function as both tumours suppressor and oncogenes. Previous studies, mainly based on microarrays technology applied on colorectal cancer cell lines, showed altered expression levels of several miRNAs in colorectal cancer (CRC). In our study, we examined by Real-Time PCR expression levels of microRNA-21 (miR-21) in tumors of 29 colorectal cancer patients. For 6 cases of CRC samples also adjacent non-tumor tissues were analyzed. For data normalization we tried different approaches (18S rRNA, GAPDH, let-7a-1). Finally, variability of let-7a-1 expression was shown to be the lowest. (en)
Title	Significance of microRNA-21 in colorectal cancer pathogenesis. Significance of microRNA-21 in colorectal cancer pathogenesis. (en)
skos:prefLabel	Significance of microRNA-21 in colorectal cancer pathogenesis. Significance of microRNA-21 in colorectal cancer pathogenesis. (en)
skos:notation	RIV/00216224:14110/08:00028239!RIV10-MZ0-14110___
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(NR9076)
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Slabý, Ondřej Růčková, Eva Vyzula, Rostislav Svoboda, Marek
http://linked.open.../riv/druhVysledku	D - Článek ve sborníku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Lékařská fakulta
http://linked.open...dnocenehoVysledku	394693
http://linked.open...ai/riv/idVysledku	RIV/00216224:14110/08:00028239
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	colorectal; microRNAs (en)
http://linked.open.../riv/klicoveSlovo	microRNAs colorectal
http://linked.open...ontrolniKodProRIV	[BC18C7BED89B]
http://linked.open...v/mistoKonaniAkce	Athens
http://linked.open...i/riv/mistoVydani	Oxford, UK
http://linked.open...i/riv/nazevZdroje	FEBS Journal
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...vavai/riv/projekt	Gene expression profiling-based prediction of treatment response for patient with locally advanced rectal cancer treated by chemotherapy and radiotherapy
http://linked.open...UplatneniVysledku	2008
http://linked.open...iv/tvurceVysledku	Dubská, Lenka Hrstka, Roman Ovesná, Jaroslava Slabý, Ondřej Růčková, Eva Svoboda, Marek Vyzula, Rostislav
http://linked.open...vavai/riv/typAkce	WRD - Světová
http://linked.open.../riv/zahajeniAkce	2008-01-01 (xsd:date)
issn	1742-464X
number of pages	1 (xsd:int)
http://purl.org/ne...btex#hasPublisher	FEBS
http://localhost/t...ganizacniJednotka	14110

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