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rdf:type
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Description
| - Although the number of verified human microRNAs (miRNAs) is still expanding, only few have been functionally described. However, emerging evidences suggest the involvement of altered regulation of miRNA in pathogenesis of cancers and these genes are thought to function as both tumours suppressor and oncogenes. Previous data suggest altered regulation of microRNA-21 (miR-21) expression in CRC. In our study, we examined by Real-Time PCR expression levels of microRNA-21 (miR-21) in 60 colorectal tumors and 40 paired adjacent non-tumor tissues and correlated them to selected clinicopathologic features and survival parameters. We used expression of U6 small nuclear RNA (RNU6B) for data normalization and standard ddCt method for relative quantification of miRNA expression. Levels of miR-21 were significantly higher in tumors comparing to normal mucosa (p < 0,0001, Wilcoxon matched-pairs test).
- Although the number of verified human microRNAs (miRNAs) is still expanding, only few have been functionally described. However, emerging evidences suggest the involvement of altered regulation of miRNA in pathogenesis of cancers and these genes are thought to function as both tumours suppressor and oncogenes. Previous data suggest altered regulation of microRNA-21 (miR-21) expression in CRC. In our study, we examined by Real-Time PCR expression levels of microRNA-21 (miR-21) in 60 colorectal tumors and 40 paired adjacent non-tumor tissues and correlated them to selected clinicopathologic features and survival parameters. We used expression of U6 small nuclear RNA (RNU6B) for data normalization and standard ddCt method for relative quantification of miRNA expression. Levels of miR-21 were significantly higher in tumors comparing to normal mucosa (p < 0,0001, Wilcoxon matched-pairs test). (en)
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Title
| - Knockdown of oncogenic microRNA-21 displays cytotoxicity in p53 wild-type colon cancer cells
- Knockdown of oncogenic microRNA-21 displays cytotoxicity in p53 wild-type colon cancer cells (en)
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skos:prefLabel
| - Knockdown of oncogenic microRNA-21 displays cytotoxicity in p53 wild-type colon cancer cells
- Knockdown of oncogenic microRNA-21 displays cytotoxicity in p53 wild-type colon cancer cells (en)
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skos:notation
| - RIV/00216224:14110/08:00028238!RIV10-MZ0-14110___
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/00216224:14110/08:00028238
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - colorectal; microRNAs (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...ontrolniKodProRIV
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http://linked.open...v/mistoKonaniAkce
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http://linked.open...i/riv/mistoVydani
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http://linked.open...i/riv/nazevZdroje
| - European Journal of Cancer Supplements
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...vavai/riv/projekt
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http://linked.open...UplatneniVysledku
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http://linked.open...iv/tvurceVysledku
| - Dubská, Lenka
- Hrstka, Roman
- Ovesná, Jaroslava
- Slabý, Ondřej
- Svoboda, Marek
- Vyzula, Rostislav
- Slabá, Kateřina
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http://linked.open...vavai/riv/typAkce
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http://linked.open.../riv/zahajeniAkce
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issn
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number of pages
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http://purl.org/ne...btex#hasPublisher
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http://localhost/t...ganizacniJednotka
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