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| Description
| - Diabetic complications including diabetic nephropathy (DN) develop due to the complex dysregulation of cellular metabolism during hyperglycemia. Accumulation of proximal glycolytic intermediates provides substrates for several alternative metabolic pathways producing harmful moieties such as advanced glycation end-products, dicarbonyls, sorbitol, hexosamines, reactive oxygen and nitrogen species etc. Pentose phosphate pathway (PPP) represents potentially %22protective%22 mechanism in hyperglycemia since shunting of cumulated glycolytic intermediates (esp. triosephosphates) into the PPP reactions quantitatively limits their processing in alternative metabolic pathways. We hypothesized that genetic variability in genes encoding key enzymes of PPP - transketolase (TKT), transaldolase, TKT-like and glucose-6-phosphate dehydrogenase - together with thiamin status (thiamine and its esters - cofactors of TKT) might contribute to an interindividual variability in the onset and progression of DN.
- Diabetic complications including diabetic nephropathy (DN) develop due to the complex dysregulation of cellular metabolism during hyperglycemia. Accumulation of proximal glycolytic intermediates provides substrates for several alternative metabolic pathways producing harmful moieties such as advanced glycation end-products, dicarbonyls, sorbitol, hexosamines, reactive oxygen and nitrogen species etc. Pentose phosphate pathway (PPP) represents potentially %22protective%22 mechanism in hyperglycemia since shunting of cumulated glycolytic intermediates (esp. triosephosphates) into the PPP reactions quantitatively limits their processing in alternative metabolic pathways. We hypothesized that genetic variability in genes encoding key enzymes of PPP - transketolase (TKT), transaldolase, TKT-like and glucose-6-phosphate dehydrogenase - together with thiamin status (thiamine and its esters - cofactors of TKT) might contribute to an interindividual variability in the onset and progression of DN. (en)
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| Title
| - Thiamine Status and Genetic Variability in the Pentose Phosphate Cycle Enzymes as Risk Factors for Diabetic Nephropathy
- Thiamine Status and Genetic Variability in the Pentose Phosphate Cycle Enzymes as Risk Factors for Diabetic Nephropathy (en)
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| skos:prefLabel
| - Thiamine Status and Genetic Variability in the Pentose Phosphate Cycle Enzymes as Risk Factors for Diabetic Nephropathy
- Thiamine Status and Genetic Variability in the Pentose Phosphate Cycle Enzymes as Risk Factors for Diabetic Nephropathy (en)
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| skos:notation
| - RIV/00216224:14110/08:00028213!RIV10-MZ0-14110___
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
| - Hertlová, Miluše
- Štěpánková, Soňa
- Olšovský, Jindřich
- Pácal, Lukáš
- Tomandl, Josef
- Dvořáková, Veronika
- Smržová, J.
- Kaňková, Kateřina
- Krusová, Darja
- Svojanovský, Jan
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
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| http://linked.open...ai/riv/idVysledku
| - RIV/00216224:14110/08:00028213
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| http://linked.open...riv/jazykVysledku
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| http://linked.open.../riv/klicovaSlova
| - diabetic nephropathy; pentose phosphate pathway; transketolase; thiamin (en)
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| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...in/vavai/riv/obor
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| http://linked.open...ichTvurcuVysledku
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| http://linked.open...cetTvurcuVysledku
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| http://linked.open...vavai/riv/projekt
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| http://linked.open...UplatneniVysledku
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| http://linked.open...iv/tvurceVysledku
| - Hertlová, Miluše
- Olšovský, Jindřich
- Tomandl, Josef
- Řehořová, Jitka
- Štěpánková, Soňa
- Kaňková, Kateřina
- Pácal, Lukáš
- Tanhäuserová, Veronika
- Krusová, Darja
- Svojanovský, Jan
- Smržová, Jana
- Šurel, Stanislav
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| http://localhost/t...ganizacniJednotka
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