About: Genetics of humoral and cytokine activation in heart failure and its importance for risk stratification of patients

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Genetics of humoral and cytokine activation in heart failure and its importance for risk stratification of patients. Patients with ischemic heart disease (IHD) and previous MI showed a difference in the distribution of genotype G8002A for endothelin-1: allele G 0.718 and A 0.282 vs those without MI: allele G 0.882 and A 0.118, (p < 0.05). Patients with IHD and DM had allele G in 0.67 and A 0.33, while those without DM had allele G in 0.790 and A in 0.209 (p < 0.03). Patients with IHD and concomitant PAD had allele G in 0.718 and A in 0.282 vs those without PAD allele G in 0.882 and A in 0.118 (p < 0.0004). Patients with dilative cardiomyopathy (DCMP) showed no differences in genotype G8002A and presence of DM or PAD. It might be speculated that in the case of endothelin-1 and TNF alpha in CHF the genetic determination is not important, and plasma concentrations are influenced more by the disease severity. Genetics of humoral and cytokine activation in heart failure and its importance for risk stratification of patients. Patients with ischemic heart disease (IHD) and previous MI showed a difference in the distribution of genotype G8002A for endothelin-1: allele G 0.718 and A 0.282 vs those without MI: allele G 0.882 and A 0.118, (p < 0.05). Patients with IHD and DM had allele G in 0.67 and A 0.33, while those without DM had allele G in 0.790 and A in 0.209 (p < 0.03). Patients with IHD and concomitant PAD had allele G in 0.718 and A in 0.282 vs those without PAD allele G in 0.882 and A in 0.118 (p < 0.0004). Patients with dilative cardiomyopathy (DCMP) showed no differences in genotype G8002A and presence of DM or PAD. It might be speculated that in the case of endothelin-1 and TNF alpha in CHF the genetic determination is not important, and plasma concentrations are influenced more by the disease severity. (en)
Title	Genetics of humoral and cytokine activation in heart failure and its importance for risk stratification of patients Genetics of humoral and cytokine activation in heart failure and its importance for risk stratification of patients (en)
skos:prefLabel	Genetics of humoral and cytokine activation in heart failure and its importance for risk stratification of patients Genetics of humoral and cytokine activation in heart failure and its importance for risk stratification of patients (en)
skos:notation	RIV/00216224:14110/08:00026223!RIV10-MSM-14110___
http://linked.open...avai/riv/aktivita	V Z
http://linked.open...avai/riv/aktivity	V, Z(MSM0021622402)
http://linked.open...iv/cisloPeriodika	7
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Ludka, Ondřej Vítovec, Jiří Tomandl, Josef Vašků, Anna Špinar, Jindřich Špinarová, Lenka Pávková Goldbergová, Monika
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Lékařská fakulta
http://linked.open...dnocenehoVysledku	369155
http://linked.open...ai/riv/idVysledku	RIV/00216224:14110/08:00026223
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Genetics; cytokines; chronic hear failure; stratification (en)
http://linked.open.../riv/klicoveSlovo	Genetics stratification cytokines chronic hear failure
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[CFBB33C50A4C]
http://linked.open...i/riv/nazevZdroje	Experimental and Molecular Pathology
http://linked.open...in/vavai/riv/obor	FA
http://linked.open...ichTvurcuVysledku	7 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...UplatneniVysledku	2008
http://linked.open...v/svazekPeriodika	84
http://linked.open...iv/tvurceVysledku	Ludka, Ondřej Tomandl, Josef Vašků, Anna Vítovec, Jiří Špinar, Jindřich Špinarová, Lenka Pávková Goldbergová, Monika
http://linked.open...ain/vavai/riv/wos	000257725700011
http://linked.open...n/vavai/riv/zamer	Early diagnostics and treatment of cardiovascular diseases
issn	0014-4800
number of pages	6 (xsd:int)
http://localhost/t...ganizacniJednotka	14110

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