About: Functional cross-talk of integrin b3 and AP-1 in differentiating osteoclasts and dendritic cells.

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About: Functional cross-talk of integrin b3 and AP-1 in differentiating osteoclasts and dendritic cells. Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Osteoclasts (OCL) and dendritic cells (DC) are highly specialized cells that originate from a common hematopoetic progenitor. The osteoclasts are involved in bone resorption; dendritic cells represent a key compound of immune system as antigen presenting cells. Despite distinct functions, similar signaling molecules are involved in control of differentiation of OCL and DC. These regulators include integrin b3, the ECM receptor, and transcription factors c-Jun and c-Fos (AP-1). To investigate the signaling crosstalk between Itgb3 and AP-1 in OCL and DC, we employed murine model of RAW264.7 macrophages. These cells differentiate to OCL or DC upon treatment with RANKL (Receptor activator of NFkB ligand)MCSF or LPS (Lipopolysacharide). Expression of itgb3, c-jun and c-fos as well as differentiation markers were determined at mRNA level by qRT-PCR or western blotting. Expression of itgb3 was induced by both RANKL MCSF and LPS; however, expression of c-fos and c-jun was regulated differently in DC and OCL. Osteoclasts (OCL) and dendritic cells (DC) are highly specialized cells that originate from a common hematopoetic progenitor. The osteoclasts are involved in bone resorption; dendritic cells represent a key compound of immune system as antigen presenting cells. Despite distinct functions, similar signaling molecules are involved in control of differentiation of OCL and DC. These regulators include integrin b3, the ECM receptor, and transcription factors c-Jun and c-Fos (AP-1). To investigate the signaling crosstalk between Itgb3 and AP-1 in OCL and DC, we employed murine model of RAW264.7 macrophages. These cells differentiate to OCL or DC upon treatment with RANKL (Receptor activator of NFkB ligand)MCSF or LPS (Lipopolysacharide). Expression of itgb3, c-jun and c-fos as well as differentiation markers were determined at mRNA level by qRT-PCR or western blotting. Expression of itgb3 was induced by both RANKL MCSF and LPS; however, expression of c-fos and c-jun was regulated differently in DC and OCL. (en)
Title	Functional cross-talk of integrin b3 and AP-1 in differentiating osteoclasts and dendritic cells. Functional cross-talk of integrin b3 and AP-1 in differentiating osteoclasts and dendritic cells. (en)
skos:prefLabel	Functional cross-talk of integrin b3 and AP-1 in differentiating osteoclasts and dendritic cells. Functional cross-talk of integrin b3 and AP-1 in differentiating osteoclasts and dendritic cells. (en)
skos:notation	RIV/00216224:14110/08:00024909!RIV11-GA0-14110___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA301/06/0036), P(GD204/08/H054), Z(MSM0021622415)
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Vaňhara, Petr Šmarda, Jan Ondroušková, Eva Vopěnková, Kateřina
http://linked.open.../riv/druhVysledku	D - Článek ve sborníku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Lékařská fakulta
http://linked.open...dnocenehoVysledku	368680
http://linked.open...ai/riv/idVysledku	RIV/00216224:14110/08:00024909
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	osteoclasts; dendritic cells; integrin beta 3; AP-1 (en)
http://linked.open.../riv/klicoveSlovo	osteoclasts dendritic cells AP-1 integrin beta 3
http://linked.open...ontrolniKodProRIV	[40E10B5AF200]
http://linked.open...v/mistoKonaniAkce	Warsaw, Poland
http://linked.open...i/riv/mistoVydani	Warsaw
http://linked.open...i/riv/nazevZdroje	Book of Abstracts
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	Molecular mechanisms of the cell proliferation and differentiation A role of certain transcription factors in the osteoclastic differentiation pathway
http://linked.open...UplatneniVysledku	2008
http://linked.open...iv/tvurceVysledku	Šmarda, Jan Ondroušková, Eva Vopěnková, Kateřina Vaňhara, Petr
http://linked.open...vavai/riv/typAkce	WRD - Světová
http://linked.open.../riv/zahajeniAkce	2008-09-10 (xsd:date)
http://linked.open...n/vavai/riv/zamer	Molecular basis of cell and tissue regulations
number of pages	2 (xsd:int)
http://purl.org/ne...btex#hasPublisher	International Life Sciences Students's Conference
https://schema.org/isbn	978-83-927731-0-8
http://localhost/t...ganizacniJednotka	14110

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