About: Genetic variations and plasma levels of the Gelatinase A (matrix metalloproteinase-2) and Gelatinase B (matrix metalloproteinase-9) in proliferative diabetic retinopathy

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About: Genetic variations and plasma levels of the Gelatinase A (matrix metalloproteinase-2) and Gelatinase B (matrix metalloproteinase-9) in proliferative diabetic retinopathy Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Purpose: The matrix metalloproteinases (MMPs) are postulated to be involved in the development of retinal angiogenesis through the regulation of extracellular matrix. The objective of the present study was to test for a possible association of five single nucleotide polymorphisms (SNPs) in the MMP-2 gene and two polymorphisms in the MMP-9 gene with proliferative diabetic retinopathy (PDR) and to determine their plasma levels. Methods: Genotypes were detected by polymerase chain reactions followed by restriction analyses with specific endonucleases and their frequencies determined in a study comprising three groups of Caucasian subjects (total n=490, diabetics with and without PDR and non-diabetics). The plasma levels of the MMP-2 and -9 proteins were analyzed by ELISA. Results: Neither MMP-2 nor MMP-9 SNPs revealed significant association with PDR in single-locus comparisons; similarly, MMP-2 haplotype frequencies did not differed significantly between groups. Purpose: The matrix metalloproteinases (MMPs) are postulated to be involved in the development of retinal angiogenesis through the regulation of extracellular matrix. The objective of the present study was to test for a possible association of five single nucleotide polymorphisms (SNPs) in the MMP-2 gene and two polymorphisms in the MMP-9 gene with proliferative diabetic retinopathy (PDR) and to determine their plasma levels. Methods: Genotypes were detected by polymerase chain reactions followed by restriction analyses with specific endonucleases and their frequencies determined in a study comprising three groups of Caucasian subjects (total n=490, diabetics with and without PDR and non-diabetics). The plasma levels of the MMP-2 and -9 proteins were analyzed by ELISA. Results: Neither MMP-2 nor MMP-9 SNPs revealed significant association with PDR in single-locus comparisons; similarly, MMP-2 haplotype frequencies did not differed significantly between groups. (en)
Title	Genetic variations and plasma levels of the Gelatinase A (matrix metalloproteinase-2) and Gelatinase B (matrix metalloproteinase-9) in proliferative diabetic retinopathy Genetic variations and plasma levels of the Gelatinase A (matrix metalloproteinase-2) and Gelatinase B (matrix metalloproteinase-9) in proliferative diabetic retinopathy (en)
skos:prefLabel	Genetic variations and plasma levels of the Gelatinase A (matrix metalloproteinase-2) and Gelatinase B (matrix metalloproteinase-9) in proliferative diabetic retinopathy Genetic variations and plasma levels of the Gelatinase A (matrix metalloproteinase-2) and Gelatinase B (matrix metalloproteinase-9) in proliferative diabetic retinopathy (en)
skos:notation	RIV/00216224:14110/08:00024690!RIV10-GA0-14110___
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(GP303/05/P523)
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Vašků, Anna Tschöplová, Svatava Beránek, Michal Kolář, Petr Kaňková, Kateřina
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Lékařská fakulta
http://linked.open...dnocenehoVysledku	369134
http://linked.open...ai/riv/idVysledku	RIV/00216224:14110/08:00024690
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	retinopathy; MMP; diabetes (en)
http://linked.open.../riv/klicoveSlovo	retinopathy diabetes MMP
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[B78F4301D7AB]
http://linked.open...i/riv/nazevZdroje	Molecular Vision
http://linked.open...in/vavai/riv/obor	FB
http://linked.open...ichTvurcuVysledku	5 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...vavai/riv/projekt	Relationship between genetic variability in candidate genes involved in angiogenesis and proliferative retinopathy in Type 2 diabetes mellitus
http://linked.open...UplatneniVysledku	2008
http://linked.open...v/svazekPeriodika	14
http://linked.open...iv/tvurceVysledku	Kolář, Petr Vašků, Anna Kaňková, Kateřina Beránek, Michal Tschöplová, Svatava
http://linked.open...ain/vavai/riv/wos	000257890500002
issn	1090-0535
number of pages	8 (xsd:int)
http://localhost/t...ganizacniJednotka	14110

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