About: Lineage specific composition of cyclin D-CDK4/CDK6-p27 complexes reveals distinct functions of CDK4, CDK6 and individual D-type cyclins in differentiating cells of embryonic origin

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About: Lineage specific composition of cyclin D-CDK4/CDK6-p27 complexes reveals distinct functions of CDK4, CDK6 and individual D-type cyclins in differentiating cells of embryonic origin Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Using P19 embryonal carcinoma cells, which we induces to differentiate either to neural or endodermal lineage, we demonstrate that composition of crucial G1/S transition regulating complexes does not reflect only proliferation parameters. Cyclin D-Cdk4/Cdk6-p27 complexes dramatically change depending on the differentiation pathways, which suggests the these complexes also regulate differentiation. Using P19 embryonal carcinoma cells, which we induces to differentiate either to neural or endodermal lineage, we demonstrate that composition of crucial G1/S transition regulating complexes does not reflect only proliferation parameters. Cyclin D-Cdk4/Cdk6-p27 complexes dramatically change depending on the differentiation pathways, which suggests the these complexes also regulate differentiation. (en)
Title	Lineage specific composition of cyclin D-CDK4/CDK6-p27 complexes reveals distinct functions of CDK4, CDK6 and individual D-type cyclins in differentiating cells of embryonic origin Lineage specific composition of cyclin D-CDK4/CDK6-p27 complexes reveals distinct functions of CDK4, CDK6 and individual D-type cyclins in differentiating cells of embryonic origin (en)
skos:prefLabel	Lineage specific composition of cyclin D-CDK4/CDK6-p27 complexes reveals distinct functions of CDK4, CDK6 and individual D-type cyclins in differentiating cells of embryonic origin Lineage specific composition of cyclin D-CDK4/CDK6-p27 complexes reveals distinct functions of CDK4, CDK6 and individual D-type cyclins in differentiating cells of embryonic origin (en)
skos:notation	RIV/00216224:14110/08:00024436!RIV10-GA0-14110___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(1M0538), P(1QS500040507), P(GA204/07/0834), P(GA301/05/0463), P(LC06077), Z(AV0Z50040507), Z(AV0Z50040702), Z(AV0Z50390512), Z(AV0Z50390703), Z(MSM0021622430)
http://linked.open...iv/cisloPeriodika	6
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Hampl, Aleš Vondráček, Jan Bryja, Vítězslav Souček, Karel Pacherník, Jiří Dvořák, Petr Holubcová, Zuzana
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Lékařská fakulta
http://linked.open...dnocenehoVysledku	376840
http://linked.open...ai/riv/idVysledku	RIV/00216224:14110/08:00024436
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	G1/S transition; cyclin D; embryonic cells differentiation (en)
http://linked.open.../riv/klicoveSlovo	G1/S transition cyclin D embryonic cells differentiation
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[EC47B31D91AF]
http://linked.open...i/riv/nazevZdroje	Cell Proliferation
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	7 (xsd:int)
http://linked.open...cetTvurcuVysledku	9 (xsd:int)
http://linked.open...vavai/riv/projekt	Lipid nutrition compounds - modulation of their effects and possibilities of practical application Center for Cell Therapy and Tissue Repair Cell cycle regulation in human embryonic stem cells - study toward establishing identifiable characteristics of high quality cells Center of Chemical Genetics Role of transforming growth factor-beta in regulation of proliferation, differentiation and apoptosis in prostate and colon cancer
http://linked.open...UplatneniVysledku	2008
http://linked.open...v/svazekPeriodika	41
http://linked.open...iv/tvurceVysledku	Bryja, Vítězslav Dvořák, Petr Hampl, Aleš Horváth, Viktor Pacherník, Jiří Souček, Karel Vondráček, Jan Holubcová, Zuzana Čajánek, Lukáš
http://linked.open...ain/vavai/riv/wos	000261140200003
http://linked.open...n/vavai/riv/zamer	Biophysics of dynamic structures and functions of biological systems Genome and epigenome: 1D and 3D Structure, Dynamics, Interactions with Proteins and Functions Molekulární, buněčné a systémové mechanizmy závažných onemocnění lidského organizmu, jejich diagnostika, terapie a farmakoterapie New biotechnologies, nanomaterials and stem cells for use in regenerative medicine Functional and molecular characteristics of cancer and normal stem cells - identification of targets for novel therapeutics and therapeutic strategies
issn	0960-7722
number of pages	19 (xsd:int)
http://localhost/t...ganizacniJednotka	14110

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