About: Functional analysis of the susceptibility haplotype in the Receptor for Advanced Glycation End-products gene and its role in the hyperglycemia-driven pathology

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About: Functional analysis of the susceptibility haplotype in the Receptor for Advanced Glycation End-products gene and its role in the hyperglycemia-driven pathology Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Background and Aims: Receptor for Advanced Glycation End-products (RAGE) belongs to the class of membrane receptors recognizing AGEs produced in accelerated rate during hyperglycemia and contributing to the development of diabetic complications. Our previous studies have shown that common haplotype in the RAGE gene (denoted RAGE2) conferred susceptibility to the development and accelerated onset of diabetic nephropathy (frequency 21.7% in nephropathy vs. 12.8% in control diabetic, P=0.015, OR=1.65 [95% CI 1.08-2.5]). The aim of the study was to elucidate the functional role of the RAGE2 susceptibility haplotype in the modulation of RAGE gene transcriptional activity. Materials and Methods: A 788bp PCR fragment of the RAGE promoter region (-738 to +49 relative to the transcription start containing the -429T/C and -374T/A polymorphic variants) was amplified using genomic DNA of homozygous subjects to create all possible haplotypes present in population (i.e. Background and Aims: Receptor for Advanced Glycation End-products (RAGE) belongs to the class of membrane receptors recognizing AGEs produced in accelerated rate during hyperglycemia and contributing to the development of diabetic complications. Our previous studies have shown that common haplotype in the RAGE gene (denoted RAGE2) conferred susceptibility to the development and accelerated onset of diabetic nephropathy (frequency 21.7% in nephropathy vs. 12.8% in control diabetic, P=0.015, OR=1.65 [95% CI 1.08-2.5]). The aim of the study was to elucidate the functional role of the RAGE2 susceptibility haplotype in the modulation of RAGE gene transcriptional activity. Materials and Methods: A 788bp PCR fragment of the RAGE promoter region (-738 to +49 relative to the transcription start containing the -429T/C and -374T/A polymorphic variants) was amplified using genomic DNA of homozygous subjects to create all possible haplotypes present in population (i.e. (en)
Title	Functional analysis of the susceptibility haplotype in the Receptor for Advanced Glycation End-products gene and its role in the hyperglycemia-driven pathology Functional analysis of the susceptibility haplotype in the Receptor for Advanced Glycation End-products gene and its role in the hyperglycemia-driven pathology (en)
skos:prefLabel	Functional analysis of the susceptibility haplotype in the Receptor for Advanced Glycation End-products gene and its role in the hyperglycemia-driven pathology Functional analysis of the susceptibility haplotype in the Receptor for Advanced Glycation End-products gene and its role in the hyperglycemia-driven pathology (en)
skos:notation	RIV/00216224:14110/08:00024278!RIV10-MSM-14110___
http://linked.open...avai/riv/aktivita	P S
http://linked.open...avai/riv/aktivity	P(KJB501620601), S
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Kuchtíčková, Šárka Beneš, Petr Kaňková, Kateřina
http://linked.open.../riv/druhVysledku	O - Ostatní výsledky nezařaditelné do žádného z výše uvedených druhů výsledku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Lékařská fakulta
http://linked.open...dnocenehoVysledku	368672
http://linked.open...ai/riv/idVysledku	RIV/00216224:14110/08:00024278
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	RAGE (en)
http://linked.open.../riv/klicoveSlovo	RAGE
http://linked.open...ontrolniKodProRIV	[4B43B8EE48DC]
http://linked.open...in/vavai/riv/obor	FB
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	3 (xsd:int)
http://linked.open...vavai/riv/projekt	Functional analysis of the RAGE gene susceptibility haplotype and its role in the hyperglycemia-driven pathology
http://linked.open...UplatneniVysledku	2008
http://linked.open...iv/tvurceVysledku	Beneš, Petr Kaňková, Kateřina Kuchtíčková, Šárka
http://localhost/t...ganizacniJednotka	14110

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