About: Perphenazine-Induced block of sodium and transient outward potassium current: experimental and simulation study

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The effect of a neuroleptic drug perphenazine on sodium current INa and transient outward potassium current Ito was studied in rat ventricular myocytes at room temperature. Perphenazine reversibly blocked INa (reducing its amplitude; IC50 = 1.24+/-0.10 micromol/l, nH = 0.99+/-0.08) and Ito (accelerating its apparent inactivation with a slight decrease of its amplitude; IC50 = 38.2+/-3.5 micromol/l, nH = 0.75+/-0.07, evaluated from the changes of time integral). Both INa- and Ito-block was use- and frequency-dependent (20%-increase of INablock and 10%-increase of Ito-block under 0.3 and 10 micromol/l perphenazine, respectively, at the stimulation frequency of 3.3 Hz applied after a 15-s rest). The results of quantitative modelling suggest that perphenazine interacts with INa-channels in inactivated states, and with Ito-channels in both open and open-inactivated states. The effect of a neuroleptic drug perphenazine on sodium current INa and transient outward potassium current Ito was studied in rat ventricular myocytes at room temperature. Perphenazine reversibly blocked INa (reducing its amplitude; IC50 = 1.24+/-0.10 micromol/l, nH = 0.99+/-0.08) and Ito (accelerating its apparent inactivation with a slight decrease of its amplitude; IC50 = 38.2+/-3.5 micromol/l, nH = 0.75+/-0.07, evaluated from the changes of time integral). Both INa- and Ito-block was use- and frequency-dependent (20%-increase of INablock and 10%-increase of Ito-block under 0.3 and 10 micromol/l perphenazine, respectively, at the stimulation frequency of 3.3 Hz applied after a 15-s rest). The results of quantitative modelling suggest that perphenazine interacts with INa-channels in inactivated states, and with Ito-channels in both open and open-inactivated states. (en)
Title	Perphenazine-Induced block of sodium and transient outward potassium current: experimental and simulation study Perphenazine-Induced block of sodium and transient outward potassium current: experimental and simulation study (en)
skos:prefLabel	Perphenazine-Induced block of sodium and transient outward potassium current: experimental and simulation study Perphenazine-Induced block of sodium and transient outward potassium current: experimental and simulation study (en)
skos:notation	RIV/00216224:14110/08:00024258!RIV10-GA0-14110___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA305/04/1385), Z(AV0Z20760514), Z(MSM0021622402)
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Jansová, Dagmar Matejovič, Peter Bébarová, Markéta Nováková, Marie Pásek, Michal Šimurda, Jiří Šimurdová, Milena
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Lékařská fakulta
http://linked.open...dnocenehoVysledku	386309
http://linked.open...ai/riv/idVysledku	RIV/00216224:14110/08:00024258
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	sodium current; potassium outward current; simulation (en)
http://linked.open.../riv/klicoveSlovo	sodium current simulation potassium outward current
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[3D65B39A32F0]
http://linked.open...i/riv/nazevZdroje	Analysis of Biomedical Signals and Images
http://linked.open...in/vavai/riv/obor	ED
http://linked.open...ichTvurcuVysledku	7 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...vavai/riv/projekt	Modulatory role of sigma signalling in electromechanical coupling of isolated cardiomyocyte and heart
http://linked.open...UplatneniVysledku	2008
http://linked.open...v/svazekPeriodika	19
http://linked.open...iv/tvurceVysledku	Bébarová, Markéta Pásek, Michal Šimurda, Jiří Nováková, Marie Šimurdová, Milena Jansová, Dagmar Matejovič, Peter
http://linked.open...n/vavai/riv/zamer	Complex dynamical systems in thermodynamics, fluid and solid mechanics Early diagnostics and treatment of cardiovascular diseases
issn	1211-412X
number of pages	5 (xsd:int)
http://localhost/t...ganizacniJednotka	14110

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