About: Quantification of t-tubule area and protein distribution in rat cardiac ventricular myocytes

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About: Quantification of t-tubule area and protein distribution in rat cardiac ventricular myocytes Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The transverse (t-) tubules of cardiac ventricular myocytes are invaginations of the surface membrane that form a complex network within the cell. Many of the key proteins involved in excitation-contraction coupling appear to be located predominantly at the t-tubule membrane. Despite their importance, the fraction of cell membrane within the ttubules remains unclear: measurement of cell capacitance following detubulation suggests 32%, whereas optical measurements suggest up to 65%. We have, therefore, investigated the factors that may account for this discrepancy. Calculation of the combinations of t-tubule radius, length and density that produce t-tubular membrane fractions of 32% or 56% suggest that the true fraction is at the upper end of this range. Assessment of detubulation using confocal and electron microscopy suggests that incomplete detubulation can account for some, but not all of the difference. The transverse (t-) tubules of cardiac ventricular myocytes are invaginations of the surface membrane that form a complex network within the cell. Many of the key proteins involved in excitation-contraction coupling appear to be located predominantly at the t-tubule membrane. Despite their importance, the fraction of cell membrane within the ttubules remains unclear: measurement of cell capacitance following detubulation suggests 32%, whereas optical measurements suggest up to 65%. We have, therefore, investigated the factors that may account for this discrepancy. Calculation of the combinations of t-tubule radius, length and density that produce t-tubular membrane fractions of 32% or 56% suggest that the true fraction is at the upper end of this range. Assessment of detubulation using confocal and electron microscopy suggests that incomplete detubulation can account for some, but not all of the difference. (en)
Title	Quantification of t-tubule area and protein distribution in rat cardiac ventricular myocytes Quantification of t-tubule area and protein distribution in rat cardiac ventricular myocytes (en)
skos:prefLabel	Quantification of t-tubule area and protein distribution in rat cardiac ventricular myocytes Quantification of t-tubule area and protein distribution in rat cardiac ventricular myocytes (en)
skos:notation	RIV/00216224:14110/08:00024218!RIV10-MSM-14110___
http://linked.open...avai/riv/aktivita	Z
http://linked.open...avai/riv/aktivity	Z(AV0Z20760514), Z(MSM0021622402)
http://linked.open...iv/cisloPeriodika	1-3
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Pásek, Michal
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Lékařská fakulta
http://linked.open...dnocenehoVysledku	391224
http://linked.open...ai/riv/idVysledku	RIV/00216224:14110/08:00024218
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	cardiac cell; transverse-axial tubular system; tubular membrane area; tubular membrane capacitance (en)
http://linked.open.../riv/klicoveSlovo	cardiac cell transverse-axial tubular system tubular membrane area tubular membrane capacitance
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[D1DB7565920A]
http://linked.open...i/riv/nazevZdroje	Progress in Biophysics and Molecular Biology
http://linked.open...in/vavai/riv/obor	BO
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...UplatneniVysledku	2008
http://linked.open...v/svazekPeriodika	96
http://linked.open...iv/tvurceVysledku	Pásek, Michal Orchard, C. Christé, G. Nelson, A. Brette, F. Pearce, C. Qaiser, A.
http://linked.open...ain/vavai/riv/wos	000254598000014
http://linked.open...n/vavai/riv/zamer	Complex dynamical systems in thermodynamics, fluid and solid mechanics Early diagnostics and treatment of cardiovascular diseases
issn	0079-6107
number of pages	14 (xsd:int)
http://localhost/t...ganizacniJednotka	14110

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