About: A model of the guinea-pig ventricular cardiac myocyte incorporating a transverse-axial tubular system

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About: A model of the guinea-pig ventricular cardiac myocyte incorporating a transverse-axial tubular system Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	A model of the guinea-pig cardiac ventricular myocyte has been developed that includes a representation of the transverse-axial tubular system (TATS), including heterogeneous distribution of ion flux pathways between the surface and tubular membranes. The model reproduces frequency-dependent changes of action potential shape and intracellular ion concentrations and can replicate experimental data showing ion diffusion between the tubular lumen and external solution in guinea-pig myocytes. The model is stable at rest and during activity and returns to rested state after perturbation. Theoretical analysis and model simulations show that, due to tight electrical coupling, tubular and surface membranes behave as a homogeneous whole during voltage and current clamp (maximum difference 0.9mV at peak tubular INa of 38 nA). However, during action potentials, restricted diffusion and ionic currents in TATS cause depletion of tubular Ca2+ and accumulation of tubular K+ (up to 19.8% and +3. A model of the guinea-pig cardiac ventricular myocyte has been developed that includes a representation of the transverse-axial tubular system (TATS), including heterogeneous distribution of ion flux pathways between the surface and tubular membranes. The model reproduces frequency-dependent changes of action potential shape and intracellular ion concentrations and can replicate experimental data showing ion diffusion between the tubular lumen and external solution in guinea-pig myocytes. The model is stable at rest and during activity and returns to rested state after perturbation. Theoretical analysis and model simulations show that, due to tight electrical coupling, tubular and surface membranes behave as a homogeneous whole during voltage and current clamp (maximum difference 0.9mV at peak tubular INa of 38 nA). However, during action potentials, restricted diffusion and ionic currents in TATS cause depletion of tubular Ca2+ and accumulation of tubular K+ (up to 19.8% and +3. (en)
Title	A model of the guinea-pig ventricular cardiac myocyte incorporating a transverse-axial tubular system A model of the guinea-pig ventricular cardiac myocyte incorporating a transverse-axial tubular system (en)
skos:prefLabel	A model of the guinea-pig ventricular cardiac myocyte incorporating a transverse-axial tubular system A model of the guinea-pig ventricular cardiac myocyte incorporating a transverse-axial tubular system (en)
skos:notation	RIV/00216224:14110/08:00024217!RIV10-MSM-14110___
http://linked.open...avai/riv/aktivita	Z
http://linked.open...avai/riv/aktivity	Z(AV0Z20760514), Z(MSM0021622402), Z(MSM0021630513)
http://linked.open...iv/cisloPeriodika	1-3
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Pásek, Michal Šimurda, Jiří
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Lékařská fakulta
http://linked.open...dnocenehoVysledku	354258
http://linked.open...ai/riv/idVysledku	RIV/00216224:14110/08:00024217
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	guinea pig; cardiac cell; transverse-axial tubular system; quantitative model (en)
http://linked.open.../riv/klicoveSlovo	guinea pig cardiac cell transverse-axial tubular system quantitative model
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[F4A1358BA9AF]
http://linked.open...i/riv/nazevZdroje	Progress in Biophysics and Molecular Biology
http://linked.open...in/vavai/riv/obor	BO
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...UplatneniVysledku	2008
http://linked.open...v/svazekPeriodika	96
http://linked.open...iv/tvurceVysledku	Pásek, Michal Šimurda, Jiří Orchard, C. Christé, G.
http://linked.open...ain/vavai/riv/wos	000254598000015
http://linked.open...n/vavai/riv/zamer	Complex dynamical systems in thermodynamics, fluid and solid mechanics Early diagnostics and treatment of cardiovascular diseases Advanced Electronic Communication Systems and Technologies (ELCOM)
issn	0079-6107
number of pages	23 (xsd:int)
http://localhost/t...ganizacniJednotka	14110

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