About: Rate constants of open channel block of cardiac transient outward current

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Numerous drugs used in clinical cardiology are blockers of membrane channels. Some of them have access to their binding sites only in open channel state. The aim of this study was to elaborate an improved approach to the assessment of association and dissociation rate constants of drug-channel interaction. The increased accuracy of the calculation of rate constants according to the newly proposed formula was verified by simulations on a quantitative model that included channel gating and drug-channel interaction. Numerous drugs used in clinical cardiology are blockers of membrane channels. Some of them have access to their binding sites only in open channel state. The aim of this study was to elaborate an improved approach to the assessment of association and dissociation rate constants of drug-channel interaction. The increased accuracy of the calculation of rate constants according to the newly proposed formula was verified by simulations on a quantitative model that included channel gating and drug-channel interaction. (en)
Title	Rate constants of open channel block of cardiac transient outward current Rate constants of open channel block of cardiac transient outward current (en)
skos:prefLabel	Rate constants of open channel block of cardiac transient outward current Rate constants of open channel block of cardiac transient outward current (en)
skos:notation	RIV/00216224:14110/07:00041745!RIV11-MSM-14110___
http://linked.open...avai/riv/aktivita	Z
http://linked.open...avai/riv/aktivity	Z(MSM0021622402)
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Šimurda, Jiří Šimurdová, Milena
http://linked.open.../riv/druhVysledku	O - Ostatní výsledky nezařaditelné do žádného z výše uvedených druhů výsledku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Lékařská fakulta
http://linked.open...dnocenehoVysledku	446440
http://linked.open...ai/riv/idVysledku	RIV/00216224:14110/07:00041745
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Transient outward current; drug-channel interaction; open channel block (en)
http://linked.open.../riv/klicoveSlovo	open channel block Transient outward current drug-channel interaction
http://linked.open...ontrolniKodProRIV	[A37F250BD774]
http://linked.open...in/vavai/riv/obor	BO
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	2 (xsd:int)
http://linked.open...UplatneniVysledku	2007
http://linked.open...iv/tvurceVysledku	Šimurda, Jiří Šimurdová, Milena
http://linked.open...n/vavai/riv/zamer	Early diagnostics and treatment of cardiovascular diseases
http://localhost/t...ganizacniJednotka	14110

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