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  • Cardiac transverse (t-) tubules form a complex network of membrane invaginations in mammalian ventricular myocytes, also known as the transverse-axial tubular system (TATS). Biophysically realistic computer models have been used to investigate experimental ambiguities and aspects of TATS function not currently amenable to experimental investigation: 1. Fraction of cell membrane within the TATS: Detubulation of rat ventricular myocytes causes a ~32% decrease of membrane capacitance whereas optical measurements suggest ~56% of the cell membrane within the TATS. Analysis of factors that may account for this discrepancy, and calculation of the combinations of t-tubule radius, length and density that produce t-tubular membrane fractions of 32% or 56%, suggest that the true fraction is at the upper end of this range. 2. Electrical coupling between the surface and TATS membranes: It has long been speculated that voltage control within the TATS may be inadequate, allowing voltage escape.
  • Cardiac transverse (t-) tubules form a complex network of membrane invaginations in mammalian ventricular myocytes, also known as the transverse-axial tubular system (TATS). Biophysically realistic computer models have been used to investigate experimental ambiguities and aspects of TATS function not currently amenable to experimental investigation: 1. Fraction of cell membrane within the TATS: Detubulation of rat ventricular myocytes causes a ~32% decrease of membrane capacitance whereas optical measurements suggest ~56% of the cell membrane within the TATS. Analysis of factors that may account for this discrepancy, and calculation of the combinations of t-tubule radius, length and density that produce t-tubular membrane fractions of 32% or 56%, suggest that the true fraction is at the upper end of this range. 2. Electrical coupling between the surface and TATS membranes: It has long been speculated that voltage control within the TATS may be inadequate, allowing voltage escape. (en)
Title
  • Modelling t-tubule function in cardiac ventricular myocytes
  • Modelling t-tubule function in cardiac ventricular myocytes (en)
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  • Modelling t-tubule function in cardiac ventricular myocytes
  • Modelling t-tubule function in cardiac ventricular myocytes (en)
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  • RIV/00216224:14110/07:00033625!RIV10-MSM-14110___
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  • 434466
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  • RIV/00216224:14110/07:00033625
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  • cardiac cell; tubular system; quantitative modelling (en)
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  • [E82AF99216E4]
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  • Orchard, Clive
  • Pásek, Michal
  • Šimurda, Jiří
  • Christé, Georges
http://linked.open...n/vavai/riv/zamer
http://localhost/t...ganizacniJednotka
  • 14110
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