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Description
| - Cardiac transverse (t-) tubules form a complex network of membrane invaginations in mammalian ventricular myocytes, also known as the transverse-axial tubular system (TATS). Biophysically realistic computer models have been used to investigate experimental ambiguities and aspects of TATS function not currently amenable to experimental investigation: 1. Fraction of cell membrane within the TATS: Detubulation of rat ventricular myocytes causes a ~32% decrease of membrane capacitance whereas optical measurements suggest ~56% of the cell membrane within the TATS. Analysis of factors that may account for this discrepancy, and calculation of the combinations of t-tubule radius, length and density that produce t-tubular membrane fractions of 32% or 56%, suggest that the true fraction is at the upper end of this range. 2. Electrical coupling between the surface and TATS membranes: It has long been speculated that voltage control within the TATS may be inadequate, allowing voltage escape.
- Cardiac transverse (t-) tubules form a complex network of membrane invaginations in mammalian ventricular myocytes, also known as the transverse-axial tubular system (TATS). Biophysically realistic computer models have been used to investigate experimental ambiguities and aspects of TATS function not currently amenable to experimental investigation: 1. Fraction of cell membrane within the TATS: Detubulation of rat ventricular myocytes causes a ~32% decrease of membrane capacitance whereas optical measurements suggest ~56% of the cell membrane within the TATS. Analysis of factors that may account for this discrepancy, and calculation of the combinations of t-tubule radius, length and density that produce t-tubular membrane fractions of 32% or 56%, suggest that the true fraction is at the upper end of this range. 2. Electrical coupling between the surface and TATS membranes: It has long been speculated that voltage control within the TATS may be inadequate, allowing voltage escape. (en)
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Title
| - Modelling t-tubule function in cardiac ventricular myocytes
- Modelling t-tubule function in cardiac ventricular myocytes (en)
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skos:prefLabel
| - Modelling t-tubule function in cardiac ventricular myocytes
- Modelling t-tubule function in cardiac ventricular myocytes (en)
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skos:notation
| - RIV/00216224:14110/07:00033625!RIV10-MSM-14110___
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/00216224:14110/07:00033625
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - cardiac cell; tubular system; quantitative modelling (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...ontrolniKodProRIV
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...UplatneniVysledku
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http://linked.open...iv/tvurceVysledku
| - Orchard, Clive
- Pásek, Michal
- Šimurda, Jiří
- Christé, Georges
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http://linked.open...n/vavai/riv/zamer
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http://localhost/t...ganizacniJednotka
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