About: Chimerism status as a possible marker of incipient disease relapse in patients with AML

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The connection between chimerism status and occurence of relapse in patients undergoing hematopoietic stem cell transplantation remains controversial. One reason for this seems to be employment of different methods with inherrited different sensitivity and related definition of complete donor chimerism (CDC). We compared an application of fragment analysis (FA) of minisatellite, microsatellite or sex specific regions (limit of quantification 1%) with real-time quantitative PCR (RQ-PCR) of insertion/deletion and sex polymorphism (limit of quantification 0.1%). Long-term data (follow-up 1.8-7.4 years, median 3.3 years) obtained from two groups of AML patients transplanted in our centre are presented. The first group involves 9 patients that experienced relapse (one of them three times) whereas the second one contains 11 individuals in complete remission. Retrospective chimerism analysis of patients in the first group by RQ-PCR allowed prediction of hematological relapse significantly earlier (p=0. The connection between chimerism status and occurence of relapse in patients undergoing hematopoietic stem cell transplantation remains controversial. One reason for this seems to be employment of different methods with inherrited different sensitivity and related definition of complete donor chimerism (CDC). We compared an application of fragment analysis (FA) of minisatellite, microsatellite or sex specific regions (limit of quantification 1%) with real-time quantitative PCR (RQ-PCR) of insertion/deletion and sex polymorphism (limit of quantification 0.1%). Long-term data (follow-up 1.8-7.4 years, median 3.3 years) obtained from two groups of AML patients transplanted in our centre are presented. The first group involves 9 patients that experienced relapse (one of them three times) whereas the second one contains 11 individuals in complete remission. Retrospective chimerism analysis of patients in the first group by RQ-PCR allowed prediction of hematological relapse significantly earlier (p=0. (en)
Title	Chimerism status as a possible marker of incipient disease relapse in patients with AML Chimerism status as a possible marker of incipient disease relapse in patients with AML (en)
skos:prefLabel	Chimerism status as a possible marker of incipient disease relapse in patients with AML Chimerism status as a possible marker of incipient disease relapse in patients with AML (en)
skos:notation	RIV/00216224:14110/07:00025698!RIV10-MSM-14110___
http://linked.open...avai/riv/aktivita	Z
http://linked.open...avai/riv/aktivity	Z(MSM0021622430)
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Horký, Ondřej Pospíšilová, Šárka Dvořáková, Dana Mayer, Jiří Krejčí, Marta
http://linked.open.../riv/druhVysledku	D - Článek ve sborníku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Lékařská fakulta
http://linked.open...dnocenehoVysledku	413516
http://linked.open...ai/riv/idVysledku	RIV/00216224:14110/07:00025698
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	microchimerism; RQ-PCR; relapse (en)
http://linked.open.../riv/klicoveSlovo	RQ-PCR microchimerism relapse
http://linked.open...ontrolniKodProRIV	[BD92BD01B427]
http://linked.open...v/mistoKonaniAkce	Atlanta
http://linked.open...i/riv/mistoVydani	Neuveden
http://linked.open...i/riv/nazevZdroje	Blood
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	5 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...UplatneniVysledku	2007
http://linked.open...iv/tvurceVysledku	Dvořáková, Dana Horký, Ondřej Krejčí, Marta Mayer, Jiří Pospíšilová, Šárka Borský, Marek
http://linked.open...vavai/riv/typAkce	WRD - Světová
http://linked.open...ain/vavai/riv/wos	000251101102320
http://linked.open.../riv/zahajeniAkce	2007-01-01 (xsd:date)
http://linked.open...n/vavai/riv/zamer	Functional and molecular characteristics of cancer and normal stem cells - identification of targets for novel therapeutics and therapeutic strategies
issn	0006-4971
number of pages	1 (xsd:int)
http://purl.org/ne...btex#hasPublisher	American Society of Hematology
http://localhost/t...ganizacniJednotka	14110

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