About: Excitation induced spatial and temporal changes of [Ca2+] in cardiac t-tubules     Goto   Sponge   NotDistinct   Permalink

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  • Majority of L-type calcium channels in ventricular cardiomyocytes are located in transverse-axial tubular system (TATS) membrane, where they are inhomogenously distributed in clusters within dyads. The aim of numeric computations (software MATLAB, version 6) was to evaluate the effect of tubular Ca2+ buffering and of inhomogeneity in Ca channel distribution on [Ca2+]t distribution. We conclude that the observation of slower velocity of Ca2+ diffusion along TATS lumen related to expected velocity considering diffusion coefficient of bulk extracellular medium) can be explained at least partly by Ca binding within TATS. The inhomogeneities in Ca2+-channel distribution in TATS due to clustering within dyads has little effect on spatial and temporal changes in [Ca2+]t induced by excitations.
  • Majority of L-type calcium channels in ventricular cardiomyocytes are located in transverse-axial tubular system (TATS) membrane, where they are inhomogenously distributed in clusters within dyads. The aim of numeric computations (software MATLAB, version 6) was to evaluate the effect of tubular Ca2+ buffering and of inhomogeneity in Ca channel distribution on [Ca2+]t distribution. We conclude that the observation of slower velocity of Ca2+ diffusion along TATS lumen related to expected velocity considering diffusion coefficient of bulk extracellular medium) can be explained at least partly by Ca binding within TATS. The inhomogeneities in Ca2+-channel distribution in TATS due to clustering within dyads has little effect on spatial and temporal changes in [Ca2+]t induced by excitations. (en)
Title
  • Excitation induced spatial and temporal changes of [Ca2+] in cardiac t-tubules
  • Excitation induced spatial and temporal changes of [Ca2+] in cardiac t-tubules (en)
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  • Excitation induced spatial and temporal changes of [Ca2+] in cardiac t-tubules
  • Excitation induced spatial and temporal changes of [Ca2+] in cardiac t-tubules (en)
skos:notation
  • RIV/00216224:14110/07:00023563!RIV11-MSM-14110___
http://linked.open...avai/riv/aktivita
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  • Z(MSM0021622402)
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  • 421024
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  • RIV/00216224:14110/07:00023563
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  • T-tubules; quantitative model; calcium difusion; cardiac cell (en)
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  • [712808C36C37]
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  • Šimurda, Jiří
  • Šimurdová, Milena
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http://localhost/t...ganizacniJednotka
  • 14110
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