About: Excitation induced spatial and temporal changes of [Ca2+] in cardiac t-tubules     Goto   Sponge   NotDistinct   Permalink

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Description
  • Vápníkové kanály typu L u srdečních komorových buněk jsou lokalizovány převážně v membránách transverzálně-axiálního tubulárního systému TATS),kde jsou rozloženy nepravidelně v klastrech v oblasti diád. Cílem numerických výpočtů na modelu popsaného parciálními diferenciálními rovnicemi bylo vyhodnotit význam vazeb vápníku v tubulech a nehomogenní distribuce Ca kanálů na změny tubulární koncentrace Ca2+. Výsledky ukázaly, že pozorovaná pomalejší rychlost difuze Ca iontů v tubulech ve srovnání s rychlostí vypočtenou pomocí difuzního koeficientu v extracelulárním mediu může být alespoň částečně vysvětlena vazbami Ca uvnitř TATS. Nehomogenity v distribuci Ca kanálů v TATS způsobené klastrováním v diádách mají jen malý vliv na prostorové a časové změny koncentrace Ca2+ v tubulech během excitace. (cs)
  • Majority of L-type calcium channels in ventricular cardiomyocytes are located in transverse-axial tubular system (TATS) membrane, where they are inhomogenously distributed in clusters within dyads. The aim of numeric computations (software MATLAB, version 6) was to evaluate the effect of tubular Ca2+ buffering and of inhomogeneity in Ca channel distribution on [Ca2+]t distribution. We conclude that the observation of slower velocity of Ca2+ diffusion along TATS lumen related to expected velocity considering diffusion coefficient of bulk extracellular medium) can be explained at least partly by Ca binding within TATS. The inhomogeneities in Ca2+-channel distribution in TATS due to clustering within dyads has little effect on spatial and temporal changes in [Ca2+]t induced by excitations.
  • Majority of L-type calcium channels in ventricular cardiomyocytes are located in transverse-axial tubular system (TATS) membrane, where they are inhomogenously distributed in clusters within dyads. The aim of numeric computations (software MATLAB, version 6) was to evaluate the effect of tubular Ca2+ buffering and of inhomogeneity in Ca channel distribution on [Ca2+]t distribution. We conclude that the observation of slower velocity of Ca2+ diffusion along TATS lumen related to expected velocity considering diffusion coefficient of bulk extracellular medium) can be explained at least partly by Ca binding within TATS. The inhomogeneities in Ca2+-channel distribution in TATS due to clustering within dyads has little effect on spatial and temporal changes in [Ca2+]t induced by excitations. (en)
Title
  • Excitation induced spatial and temporal changes of [Ca2+] in cardiac t-tubules
  • Excitation induced spatial and temporal changes of [Ca2+] in cardiac t-tubules (en)
  • Prostorové a časové změny [Ca2+] v srdečních t-tubulech vyvolané excitací (cs)
skos:prefLabel
  • Excitation induced spatial and temporal changes of [Ca2+] in cardiac t-tubules
  • Excitation induced spatial and temporal changes of [Ca2+] in cardiac t-tubules (en)
  • Prostorové a časové změny [Ca2+] v srdečních t-tubulech vyvolané excitací (cs)
skos:notation
  • RIV/00216224:14110/07:00023563!RIV09-MSM-14110___
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • Z(MSM0021622402)
http://linked.open...iv/cisloPeriodika
  • 3
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 421025
http://linked.open...ai/riv/idVysledku
  • RIV/00216224:14110/07:00023563
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • T-tubules; quantitative model; calcium difusion; cardiac cell (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • CZ - Česká republika
http://linked.open...ontrolniKodProRIV
  • [2EDFC19F75B5]
http://linked.open...i/riv/nazevZdroje
  • Physiological Research
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 56
http://linked.open...iv/tvurceVysledku
  • Šimurda, Jiří
  • Šimurdová, Milena
http://linked.open...n/vavai/riv/zamer
issn
  • 0862-8408
number of pages
http://localhost/t...ganizacniJednotka
  • 14110
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