About: Characterization of human embryonic stem cell lines by the International Stem Cell Initiative

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	This study represents the result of the first international comparison of a large number of lines of human embryonic (ES) stem cells from laboratories worldwide that has been accomplished with the aim to reveal and characterize their similarities and/or differences. In this study, we have analyzed 59 independently derived human ES cell lines, from 17 laboratories in 11 countries. Our data show that despite diverse genotypes and different techniques used for derivation and maintenance, all lines exhibit similar expression patterns for several markers of human ES cells. Nevertheless, the lines were not identical: differences in expression of several lineage-specific markers were evident, and several imprinted genes showed generally similar allele-specific expression patterns. This study sets grounds for further international collaboration toward the future use of human ES cells in regenerative medicine, drug discovery and toxicology. This study represents the result of the first international comparison of a large number of lines of human embryonic (ES) stem cells from laboratories worldwide that has been accomplished with the aim to reveal and characterize their similarities and/or differences. In this study, we have analyzed 59 independently derived human ES cell lines, from 17 laboratories in 11 countries. Our data show that despite diverse genotypes and different techniques used for derivation and maintenance, all lines exhibit similar expression patterns for several markers of human ES cells. Nevertheless, the lines were not identical: differences in expression of several lineage-specific markers were evident, and several imprinted genes showed generally similar allele-specific expression patterns. This study sets grounds for further international collaboration toward the future use of human ES cells in regenerative medicine, drug discovery and toxicology. (en)
Title	Characterization of human embryonic stem cell lines by the International Stem Cell Initiative Characterization of human embryonic stem cell lines by the International Stem Cell Initiative (en)
skos:prefLabel	Characterization of human embryonic stem cell lines by the International Stem Cell Initiative Characterization of human embryonic stem cell lines by the International Stem Cell Initiative (en)
skos:notation	RIV/00216224:14110/07:00023516!RIV10-GA0-14110___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(1M0538), P(GA301/05/0463), P(GA305/05/0434), P(LC06077), Z(AV0Z50390512)
http://linked.open...iv/cisloPeriodika	7
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Hampl, Aleš Dvořák, Petr
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Lékařská fakulta
http://linked.open...dnocenehoVysledku	413338
http://linked.open...ai/riv/idVysledku	RIV/00216224:14110/07:00023516
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	human; embryonic; stem cell (en)
http://linked.open.../riv/klicoveSlovo	stem cell human embryonic
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[408A856BB990]
http://linked.open...i/riv/nazevZdroje	Nature biotechnology
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	85 (xsd:int)
http://linked.open...vavai/riv/projekt	Center for Cell Therapy and Tissue Repair Cell cycle regulation in human embryonic stem cells - study toward establishing identifiable characteristics of high quality cells Fibroblast growth factor signaling pathways in human embryonic stem cells Center of Chemical Genetics
http://linked.open...UplatneniVysledku	2007
http://linked.open...v/svazekPeriodika	25
http://linked.open...iv/tvurceVysledku	Dvořák, Petr Ford, A. Hampl, Aleš Patel, H. … Andrews, P. W. Benvenisty, N. Churchill, G. A. Nagy, A. Patel, M. Jones, M. Hovatta, O. Itskovitz-Eldor, J. Moore, H. D. Otonkoski, T. Knowles, B. B. Adewumi, O. Aflatoonian, B. Ahrlund-Richter, L. Amit, M. Beighton, G. Bello, P. A. Berry, L. S. Bevan, S. Blum, B. Brooking, J. Chen, K. G. Choo, A. B. Corbel, M. Damjanov, I. Draper, J. S. Emanuelsson, K. Fleck, R. A. Gertow, K. Gertsenstein, M. Gokhale, P. J. Hamilton, R. S. Healy, L. E. Hyllner, J. Imreh, M. P. Jackson, J. Johnson, J. L. Kee, K. King, B. L. Lako, M. Lebrin, F. Mallon, B. S. Manning, D. Mayshar, Y. McKay, R. D. Michalska, A. E. Mikkola, M. Mileikovsky, M. Minger, S. L. Mummery, C. L. Nakatsuji, N. O'Brien, C. M. Oh, S. K. Olsson, C. Park, K. Y. Passier, R. Pedersen, R.

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