About: THE INFLUENCE OF METHANANDAMIDE AND SEX ON THE ACTIVITY OF CYTOCHROME P 450 AS A PREDICTIVE FACTOR OF XENOBIOTICS TOXICITY

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The primary active constituent of the hemp plant Cannabis sativa is 9-tetrahydrocannabinol (THC)1. Anandamide, an endogenous ligand for brain cannabinoid CB1 receptor, produces many behavioural effects similar to those of THC. (R)-(+)-methanandamide (MET) is a synthetic long-lasting arachidonylethanolamide (anandamide) analogue. The enzymatic system of cytochrome P450 (CYP450) is part of phase I of enzymatic biotransformation. Interindividual variability of activity of oxidative and conjugating enzymes, especially the system of CYP450, can be based on many exogenous as well as endogenous influences e.g. sex, age or genetic factors. The aim of this work was to investigate the effect of repeated administration of (MET) on rat liver CYP2D2 isoenzyme using dextromethorphan (DEM) as a specific marker4. We have also studied the role of sex on the activity of CYP2D2 isoenzyme. The activity of CYP2D2 differed due to pretreatment with methanandamide. The primary active constituent of the hemp plant Cannabis sativa is 9-tetrahydrocannabinol (THC)1. Anandamide, an endogenous ligand for brain cannabinoid CB1 receptor, produces many behavioural effects similar to those of THC. (R)-(+)-methanandamide (MET) is a synthetic long-lasting arachidonylethanolamide (anandamide) analogue. The enzymatic system of cytochrome P450 (CYP450) is part of phase I of enzymatic biotransformation. Interindividual variability of activity of oxidative and conjugating enzymes, especially the system of CYP450, can be based on many exogenous as well as endogenous influences e.g. sex, age or genetic factors. The aim of this work was to investigate the effect of repeated administration of (MET) on rat liver CYP2D2 isoenzyme using dextromethorphan (DEM) as a specific marker4. We have also studied the role of sex on the activity of CYP2D2 isoenzyme. The activity of CYP2D2 differed due to pretreatment with methanandamide. (en)
Title	THE INFLUENCE OF METHANANDAMIDE AND SEX ON THE ACTIVITY OF CYTOCHROME P 450 AS A PREDICTIVE FACTOR OF XENOBIOTICS TOXICITY THE INFLUENCE OF METHANANDAMIDE AND SEX ON THE ACTIVITY OF CYTOCHROME P 450 AS A PREDICTIVE FACTOR OF XENOBIOTICS TOXICITY (en)
skos:prefLabel	THE INFLUENCE OF METHANANDAMIDE AND SEX ON THE ACTIVITY OF CYTOCHROME P 450 AS A PREDICTIVE FACTOR OF XENOBIOTICS TOXICITY THE INFLUENCE OF METHANANDAMIDE AND SEX ON THE ACTIVITY OF CYTOCHROME P 450 AS A PREDICTIVE FACTOR OF XENOBIOTICS TOXICITY (en)
skos:notation	RIV/00216224:14110/07:00023389!RIV10-MSM-14110___
http://linked.open...avai/riv/aktivita	Z
http://linked.open...avai/riv/aktivity	Z(MSM0021622404)
http://linked.open...iv/cisloPeriodika	14
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Juřica, Jan Zendulka, Ondřej Zahradníková, Lucia McCaskey Hadašová, Eva
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Lékařská fakulta
http://linked.open...dnocenehoVysledku	426299
http://linked.open...ai/riv/idVysledku	RIV/00216224:14110/07:00023389
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	(R)-(+)-Methanandamide/ cytochrome P 450/ isolated perfused rat liver/ sex difference (en)
http://linked.open.../riv/klicoveSlovo	(R)-(+)-Methanandamide/ cytochrome P 450/ isolated perfused rat liver/ sex difference
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[A44CA942E76C]
http://linked.open...i/riv/nazevZdroje	Chemické listy
http://linked.open...in/vavai/riv/obor	FR
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...UplatneniVysledku	2007
http://linked.open...v/svazekPeriodika	101
http://linked.open...iv/tvurceVysledku	Juřica, Jan Zendulka, Ondřej Zahradníková, Lucia McCaskey Hadašová, Eva
http://linked.open...n/vavai/riv/zamer	The Internal Organisation and Neurobiological Mechanisms of Functional CNS Systems under Normal and Pathological Conditions
issn	0009-2770
number of pages	3 (xsd:int)
http://localhost/t...ganizacniJednotka	14110

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