About: Links among paroxetine-induced sexual dysfunctions, gender, and CYP2D6 activity     Goto   Sponge   NotDistinct   Permalink

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Description
  • The aim of the study was to compare the distribution of therapeutic efficacy and sexual dysfunction during maintenance paroxetine treatment in 17 males and 38 females genotyped and phenotyped to determine their CYP2D6 metabolic status. The phenotype procedure showed 7 males and 12 females with extensive metabolic status (EM) and 10 males and 26 females with poor metabolic status (PM). No variation in therapeutic efficacy between male and female subjects classified as PM and those marked as EM was found. A significantly higher rate of sexual dysfunction (p=0,01) was recorded among females with a PM phenotype.
  • The aim of the study was to compare the distribution of therapeutic efficacy and sexual dysfunction during maintenance paroxetine treatment in 17 males and 38 females genotyped and phenotyped to determine their CYP2D6 metabolic status. The phenotype procedure showed 7 males and 12 females with extensive metabolic status (EM) and 10 males and 26 females with poor metabolic status (PM). No variation in therapeutic efficacy between male and female subjects classified as PM and those marked as EM was found. A significantly higher rate of sexual dysfunction (p=0,01) was recorded among females with a PM phenotype. (en)
Title
  • Links among paroxetine-induced sexual dysfunctions, gender, and CYP2D6 activity
  • Links among paroxetine-induced sexual dysfunctions, gender, and CYP2D6 activity (en)
skos:prefLabel
  • Links among paroxetine-induced sexual dysfunctions, gender, and CYP2D6 activity
  • Links among paroxetine-induced sexual dysfunctions, gender, and CYP2D6 activity (en)
skos:notation
  • RIV/00216224:14110/07:00022464!RIV10-MSM-14110___
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • Z(MSM0021622404)
http://linked.open...iv/cisloPeriodika
  • 5
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 431155
http://linked.open...ai/riv/idVysledku
  • RIV/00216224:14110/07:00022464
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • paroxetine - CYP2D6 - gender - sexual dysfunction (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • US - Spojené státy americké
http://linked.open...ontrolniKodProRIV
  • [0870FD3F0FA3]
http://linked.open...i/riv/nazevZdroje
  • Journal of Sex and Marital Therapy
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 33
http://linked.open...iv/tvurceVysledku
  • Ravčuková, Barbora
  • Češková, Eva
  • Žourková, Alexandra
  • McCaskey Hadašová, Eva
http://linked.open...ain/vavai/riv/wos
  • 000247599700006
http://linked.open...n/vavai/riv/zamer
issn
  • 0092-623X
number of pages
http://localhost/t...ganizacniJednotka
  • 14110
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