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Description
  • The hypertrophy of vascular smooth muscle cells as well as neointimal proliferation is critical in vascular remodeling, whereas leptin has proved to play an important role recently. The aim of the study was to investigate possible associations of two common leptin gene polymorphisms with restenosis after percutaneous coronary intervention (PCI). To study the association of two promoter polymorphisms, LEP 2548 G/A and LEP 188 C/A (dbSNP ID rs7799039 and rs791620) with neointimal proliferation in humans, 98 consecutive patients undergoing stenting into small coronary arteries (<3 mm) were genotyped. After a 6 month follow up, the restenosis rate was estimated. Restenosis >50% occurred in 33.3% of patients carrying both A alleles, 33.3% of carriers of A and C alleles, and 31.4% of carriers of two CC alleles of LEP 188 C/A polymorphism; and in 25.0% of patients with AA, 32.7% with AG, and 30.4% with GG genotype of LEP 2548 G/A polymorphism.
  • The hypertrophy of vascular smooth muscle cells as well as neointimal proliferation is critical in vascular remodeling, whereas leptin has proved to play an important role recently. The aim of the study was to investigate possible associations of two common leptin gene polymorphisms with restenosis after percutaneous coronary intervention (PCI). To study the association of two promoter polymorphisms, LEP 2548 G/A and LEP 188 C/A (dbSNP ID rs7799039 and rs791620) with neointimal proliferation in humans, 98 consecutive patients undergoing stenting into small coronary arteries (<3 mm) were genotyped. After a 6 month follow up, the restenosis rate was estimated. Restenosis >50% occurred in 33.3% of patients carrying both A alleles, 33.3% of carriers of A and C alleles, and 31.4% of carriers of two CC alleles of LEP 188 C/A polymorphism; and in 25.0% of patients with AA, 32.7% with AG, and 30.4% with GG genotype of LEP 2548 G/A polymorphism. (en)
Title
  • Are common leptin promoter polymorphisms associated with restenosis after coronary stenting?
  • Are common leptin promoter polymorphisms associated with restenosis after coronary stenting? (en)
skos:prefLabel
  • Are common leptin promoter polymorphisms associated with restenosis after coronary stenting?
  • Are common leptin promoter polymorphisms associated with restenosis after coronary stenting? (en)
skos:notation
  • RIV/00216224:14110/07:00022111!RIV10-MSM-14110___
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • Z(MSM 141100002)
http://linked.open...iv/cisloPeriodika
  • 22(5)
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 410701
http://linked.open...ai/riv/idVysledku
  • RIV/00216224:14110/07:00022111
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • leptin; restenosis; gene; polymorphism (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • JP - Japonsko
http://linked.open...ontrolniKodProRIV
  • [9F6BBEF61019]
http://linked.open...i/riv/nazevZdroje
  • Heart Vessels
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 2007
http://linked.open...iv/tvurceVysledku
  • Bienertová Vašků, Julie
  • Vašků, Anna
  • Hlinomaz, Ota
http://linked.open...n/vavai/riv/zamer
issn
  • 0910-8327
number of pages
http://localhost/t...ganizacniJednotka
  • 14110
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