About: Three Retionoid X Receptor Gene Polymorphisms in Plaque Psoriasis and Psoriasis Guttata     Goto   Sponge   NotDistinct   Permalink

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  • Aim: Polymorphisms in RXRs are very interesting from the point of view of possible association of their variability with psoriasis. Methods: The total of 293 patients with plaque psoriasis, 82 patients with psoriasis guttata and 202 control subjects have been enrolled in this study focused on three polymorphisms in RXRA and RXRB genes associations. Results: A marginally significant increase in AA allelic frequency of RXRA A(39526)AA polymorphism in plaque psoriatic men compared to healthy ones was proved. In women with psoriasis guttata, the higher risk for genotypes AA and TT in RXRB 3+ 140A/T polymorphism compared to healthy women was identified ( Pcorr=0.01). The genotypes A/A and AA/AA are more frequent in plaque psoriasis patients with positive family history of psoriasis compared to the patients with negative family history of psoriasis (Pcorr=0.02). The A/A genotype is more frequent in patients with plaque psoriasis and repeated tonsillitis/tonsillectomia (P=0.02).
  • Aim: Polymorphisms in RXRs are very interesting from the point of view of possible association of their variability with psoriasis. Methods: The total of 293 patients with plaque psoriasis, 82 patients with psoriasis guttata and 202 control subjects have been enrolled in this study focused on three polymorphisms in RXRA and RXRB genes associations. Results: A marginally significant increase in AA allelic frequency of RXRA A(39526)AA polymorphism in plaque psoriatic men compared to healthy ones was proved. In women with psoriasis guttata, the higher risk for genotypes AA and TT in RXRB 3+ 140A/T polymorphism compared to healthy women was identified ( Pcorr=0.01). The genotypes A/A and AA/AA are more frequent in plaque psoriasis patients with positive family history of psoriasis compared to the patients with negative family history of psoriasis (Pcorr=0.02). The A/A genotype is more frequent in patients with plaque psoriasis and repeated tonsillitis/tonsillectomia (P=0.02). (en)
Title
  • Three Retionoid X Receptor Gene Polymorphisms in Plaque Psoriasis and Psoriasis Guttata
  • Three Retionoid X Receptor Gene Polymorphisms in Plaque Psoriasis and Psoriasis Guttata (en)
skos:prefLabel
  • Three Retionoid X Receptor Gene Polymorphisms in Plaque Psoriasis and Psoriasis Guttata
  • Three Retionoid X Receptor Gene Polymorphisms in Plaque Psoriasis and Psoriasis Guttata (en)
skos:notation
  • RIV/00216224:14110/07:00021770!RIV10-MSM-14110___
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • Z(MSM 141100002)
http://linked.open...iv/cisloPeriodika
  • 214
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 455138
http://linked.open...ai/riv/idVysledku
  • RIV/00216224:14110/07:00021770
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • Retinoid X receptor gene polymorphism; psoriasis; early onset; tonsillitis; family history (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • CH - Švýcarská konfederace
http://linked.open...ontrolniKodProRIV
  • [755B608470AF]
http://linked.open...i/riv/nazevZdroje
  • Dermatology
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 02/2007
http://linked.open...iv/tvurceVysledku
  • Bienertová Vašků, Julie
  • Vašků, Anna
  • Vašků, Vladimír
  • Pávková Goldbergová, Monika
http://linked.open...ain/vavai/riv/wos
  • 000244747600004
http://linked.open...n/vavai/riv/zamer
issn
  • 1018-8665
number of pages
http://localhost/t...ganizacniJednotka
  • 14110
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