About: Effects of sigma receptor ligand BD737 in rat isolated hearts

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The present study was focused on possible effects of highly selective, high affinity sigma receptor ligand BD737 in rat isolated hearts perfused according to Langendorff. Electrogram recorded by touch-less method and left ventricular pressure acquired by balloon method were followed during acute exposure of isolated rat heart to nanomolar concentrations of the drug. Ventricular ectopic beats and periods of bigeminy were present in all experiments. Moreover, heart rate fluctuations were observed. In analogy to the positive inotropic effect previously described in isolated rat cardiomyocytes, BD737 exerted a slight insignificant increase of systolic pressure in our experimental model. In conclusion, the inotropic and chronotropic effects of sigma ligand BD737 in nanomolar concentration were confirmed in isolated rat hearts. The present study was focused on possible effects of highly selective, high affinity sigma receptor ligand BD737 in rat isolated hearts perfused according to Langendorff. Electrogram recorded by touch-less method and left ventricular pressure acquired by balloon method were followed during acute exposure of isolated rat heart to nanomolar concentrations of the drug. Ventricular ectopic beats and periods of bigeminy were present in all experiments. Moreover, heart rate fluctuations were observed. In analogy to the positive inotropic effect previously described in isolated rat cardiomyocytes, BD737 exerted a slight insignificant increase of systolic pressure in our experimental model. In conclusion, the inotropic and chronotropic effects of sigma ligand BD737 in nanomolar concentration were confirmed in isolated rat hearts. (en)
Title	Effects of sigma receptor ligand BD737 in rat isolated hearts Effects of sigma receptor ligand BD737 in rat isolated hearts (en)
skos:prefLabel	Effects of sigma receptor ligand BD737 in rat isolated hearts Effects of sigma receptor ligand BD737 in rat isolated hearts (en)
skos:notation	RIV/00216224:14110/07:00020696!RIV10-GA0-14110___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA102/07/1473), Z(MSM0021622402)
http://linked.open...iv/cisloPeriodika	6
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Nováková, Marie
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Lékařská fakulta
http://linked.open...dnocenehoVysledku	419300
http://linked.open...ai/riv/idVysledku	RIV/00216224:14110/07:00020696
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Isolated heart; sigma receptor; electrogram; arrhythmias; rat (en)
http://linked.open.../riv/klicoveSlovo	sigma receptor Isolated heart arrhythmias rat electrogram
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[6C0BE34B13C8]
http://linked.open...i/riv/nazevZdroje	Scripta medica
http://linked.open...in/vavai/riv/obor	ED
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	1 (xsd:int)
http://linked.open...vavai/riv/projekt	Optical Methods for Registration of Heart Electrical Potentials and Calcium Concentration with Laser Stabilization
http://linked.open...UplatneniVysledku	2007
http://linked.open...v/svazekPeriodika	80
http://linked.open...iv/tvurceVysledku	Nováková, Marie
http://linked.open...n/vavai/riv/zamer	Early diagnostics and treatment of cardiovascular diseases
issn	1211-3395
number of pages	8 (xsd:int)
http://localhost/t...ganizacniJednotka	14110

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