About: Genetic risk factors for diabetic nephropathy on chromosomes 6p and 7q identified by the set-association approach

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About: Genetic risk factors for diabetic nephropathy on chromosomes 6p and 7q identified by the set-association approach Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Aims: We studied association of a set of 45 SNPs in 20 candidate genes on 8 chromosomes with diabetic nephropathy (DN) in type 2 diabetes mellitus. We aimed to compare two methodological approaches suitable for analysing susceptibility to complex traits - single vs. multilocus analysis. Methods: The study comprised a total of 647 in one of the three groups: diabetics with or without DN or non-diabetics. Genotypes were detected by PCR-based methodology (PCR only, PCR + RFLP or allele-specific PCR). Haplotypes were inferred in silico, Set association (programme SUMSTAT) was used for multilocus analysis. Results: After correction for multiple comparisons, one SNP only - RAGE 2184A/G (AGER gene) - showed a significant association with DN (p=0.0006) in single-locus analysis. In multilocus analysis, six SNPs exhibited significant association with DN: 4 SNPs on chromosome 6p (AGER 2184A/G, LTA 252A/G, EDN1 8002G/A, and AGER -429T/C) and 2 SNPs on chromosome 7q (NOS3 774C/T and NOS3 E298D), omnibus p=0.033. Aims: We studied association of a set of 45 SNPs in 20 candidate genes on 8 chromosomes with diabetic nephropathy (DN) in type 2 diabetes mellitus. We aimed to compare two methodological approaches suitable for analysing susceptibility to complex traits - single vs. multilocus analysis. Methods: The study comprised a total of 647 in one of the three groups: diabetics with or without DN or non-diabetics. Genotypes were detected by PCR-based methodology (PCR only, PCR + RFLP or allele-specific PCR). Haplotypes were inferred in silico, Set association (programme SUMSTAT) was used for multilocus analysis. Results: After correction for multiple comparisons, one SNP only - RAGE 2184A/G (AGER gene) - showed a significant association with DN (p=0.0006) in single-locus analysis. In multilocus analysis, six SNPs exhibited significant association with DN: 4 SNPs on chromosome 6p (AGER 2184A/G, LTA 252A/G, EDN1 8002G/A, and AGER -429T/C) and 2 SNPs on chromosome 7q (NOS3 774C/T and NOS3 E298D), omnibus p=0.033. (en)
Title	Genetic risk factors for diabetic nephropathy on chromosomes 6p and 7q identified by the set-association approach Genetic risk factors for diabetic nephropathy on chromosomes 6p and 7q identified by the set-association approach (en)
skos:prefLabel	Genetic risk factors for diabetic nephropathy on chromosomes 6p and 7q identified by the set-association approach Genetic risk factors for diabetic nephropathy on chromosomes 6p and 7q identified by the set-association approach (en)
skos:notation	RIV/00216224:14110/07:00020074!RIV10-GA0-14110___
http://linked.open...avai/riv/aktivita	P S Z
http://linked.open...avai/riv/aktivity	P(GA310/06/0827), P(GP303/02/D127), P(GP303/05/P523), P(NR9443), S, Z(MSM 141100002)
http://linked.open...iv/cisloPeriodika	5
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Hertlová, Miluše Izakovičová-Hollá, Lydie Pácal, Lukáš Vašků, Anna Tschöplová, Svatava Stejskalová, Andrea Beránek, Michal Kaňková, Kateřina Krusová, Darja
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Lékařská fakulta
http://linked.open...dnocenehoVysledku	423137
http://linked.open...ai/riv/idVysledku	RIV/00216224:14110/07:00020074
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	diabetic nephropathy; endothelin; haplotype; LTA; lymphotoxin A; nitric oxide synthase; NOS3; RAGE; Receptor of Advanced Glycation End products; set-association (en)
http://linked.open.../riv/klicoveSlovo	haplotype nitric oxide synthase endothelin RAGE diabetic nephropathy LTA NOS3 Receptor of Advanced Glycation End products lymphotoxin A set-association
http://linked.open...odStatuVydavatele	DE - Spolková republika Německo
http://linked.open...ontrolniKodProRIV	[15D7D0FE30A3]
http://linked.open...i/riv/nazevZdroje	Diabetologia
http://linked.open...in/vavai/riv/obor	FB
http://linked.open...ichTvurcuVysledku	9 (xsd:int)
http://linked.open...cetTvurcuVysledku	11 (xsd:int)
http://linked.open...vavai/riv/projekt	Genetic variability of pentose phosphate pathway as a modulating factor of the onset and progression of diabetic nephropathy Genetic determinants of the pro-/antioxidant balance in the pathogenesis of respiratory diseases Relationship between genetic variability of antioxidant system and late complications of diabetes mellitus Relationship between genetic variability in candidate genes involved in angiogenesis and proliferative retinopathy in Type 2 diabetes mellitus
http://linked.open...UplatneniVysledku	2007
http://linked.open...v/svazekPeriodika	50
http://linked.open...iv/tvurceVysledku	Hertlová, Miluše Izakovičová-Hollá, Lydie Vašků, Anna Kaňková, Kateřina Pácal, Lukáš Krusová, Darja Beránek, Michal Tschöplová, Svatava Stejskalová, Andrea Ott, Jurg Barral-Rodriguez, Sandra
http://linked.open...ain/vavai/riv/wos	000245521400014
http://linked.open...n/vavai/riv/zamer	http://linked.opendata.cz/resource/domain/vavai/zamer/MSM%20141100002
issn	0012-186X
number of pages	10 (xsd:int)
http://localhost/t...ganizacniJednotka	14110

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