About: Lymphocyte showing the phenotype of regulatory T-cells infiltrate colon carcinoma

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	We have previously shown that colon carcinoma (CC) is infiltrated by FOXP3-positive lymphocytes. Although the transcription factor FOXP3 is claimed to be specific for regulatory T (TREG) cells, the canonical TREG population is known to show the CD4+ CD25+ (FOXP3+) immunophenotype. The aim of the current study was therefore to investigate whether FOXP3+ cells infiltrating CC coexpress indeed CD4 and CD25 molecules. Double-staining experiments were therefore performed on serial sections obtained from formalin-fixed, paraffin-embedded specimens of nine cases of CC. The CC infiltrate included numerous CD4+ as well as CD25+ cells; moreover CD4+ cells harboured both FOXP3+ and FOXP3- lymphocytes; similarly, CD25+ cells included both FOXP3+ and FOXP3- lymphocytes. Nevertheless, all the FOXP3+ cells showed simultaneously CD4-positivity; similarly, all the FOXP3+ cells showed simultaneously CD25-positivity. We have previously shown that colon carcinoma (CC) is infiltrated by FOXP3-positive lymphocytes. Although the transcription factor FOXP3 is claimed to be specific for regulatory T (TREG) cells, the canonical TREG population is known to show the CD4+ CD25+ (FOXP3+) immunophenotype. The aim of the current study was therefore to investigate whether FOXP3+ cells infiltrating CC coexpress indeed CD4 and CD25 molecules. Double-staining experiments were therefore performed on serial sections obtained from formalin-fixed, paraffin-embedded specimens of nine cases of CC. The CC infiltrate included numerous CD4+ as well as CD25+ cells; moreover CD4+ cells harboured both FOXP3+ and FOXP3- lymphocytes; similarly, CD25+ cells included both FOXP3+ and FOXP3- lymphocytes. Nevertheless, all the FOXP3+ cells showed simultaneously CD4-positivity; similarly, all the FOXP3+ cells showed simultaneously CD25-positivity. (en)
Title	Lymphocyte showing the phenotype of regulatory T-cells infiltrate colon carcinoma Lymphocyte showing the phenotype of regulatory T-cells infiltrate colon carcinoma (en)
skos:prefLabel	Lymphocyte showing the phenotype of regulatory T-cells infiltrate colon carcinoma Lymphocyte showing the phenotype of regulatory T-cells infiltrate colon carcinoma (en)
skos:notation	RIV/00216224:14110/07:00019123!RIV10-MZ0-14110___
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(NR9076)
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Hanzelková, Zina Slabý, Ondřej Garajová, Ingrid Vyzula, Rostislav Svoboda, Marek Kocáková, Ilona Fabian, Pavel Nenutil, Rudolf Grell, Peter
http://linked.open.../riv/druhVysledku	O - Ostatní výsledky nezařaditelné do žádného z výše uvedených druhů výsledku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Lékařská fakulta
http://linked.open...dnocenehoVysledku	431566
http://linked.open...ai/riv/idVysledku	RIV/00216224:14110/07:00019123
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	regulatory T-cells; colon carcinoma (en)
http://linked.open.../riv/klicoveSlovo	regulatory T-cells colon carcinoma
http://linked.open...ontrolniKodProRIV	[67A46A6078E8]
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	9 (xsd:int)
http://linked.open...cetTvurcuVysledku	9 (xsd:int)
http://linked.open...vavai/riv/projekt	Gene expression profiling-based prediction of treatment response for patient with locally advanced rectal cancer treated by chemotherapy and radiotherapy
http://linked.open...UplatneniVysledku	2007
http://linked.open...iv/tvurceVysledku	Slabý, Ondřej Svoboda, Marek Vyzula, Rostislav Kocáková, Ilona Fabian, Pavel Nenutil, Rudolf Grell, Peter Garajová, Ingrid Hanzelková, Zina
http://localhost/t...ganizacniJednotka	14110

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