About: ASSOCIATION BETWEEN CHROMOSOMAL CHANGES AND STANDARD PROGNOSTIC FACTORS IN PATIENTS WITH MULTIPLE MYELOMA UNDERGOING AUTOLOGOUS STEM CELL TRANSPLANTATION

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About: ASSOCIATION BETWEEN CHROMOSOMAL CHANGES AND STANDARD PROGNOSTIC FACTORS IN PATIENTS WITH MULTIPLE MYELOMA UNDERGOING AUTOLOGOUS STEM CELL TRANSPLANTATION Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Background Cytogenetic abnormalities in multiple myeloma (MM) are one of the most important independent prognostic factors. Based on cytogenetic findings MM patients (pts.) could be divided into prognostic groups. Aims To determine the correlation between the aberration of the chromosome 13, rearrangement of IGH gene, translocations t(11;14) and t(4;14), the deletion of 17p13 and the prognostic factors in the patients with newly diagnosed MM who underwent autologous transplantation (AT) according protocol of CMG 2002 trial. Methods Fluorescence in situ hybridization and cytoplasm immunoglobulin staining (cIg-FISH) were used to detect monotypic plasma cells and aberrations mentioned above. Cytogenetic abnormalities were found in 70 newly diagnosed patients with MM, median of follow-up 17.5 months, median age 57 years (39-67), DS stadium: stage I 7.1%, II 24.3%, III 68.6%; A/B - 84.3%/15.7%. Results Overall response (OR) rate after AT was 78.5% including 13% CR, 27% VGPR and 38.5% PR. Background Cytogenetic abnormalities in multiple myeloma (MM) are one of the most important independent prognostic factors. Based on cytogenetic findings MM patients (pts.) could be divided into prognostic groups. Aims To determine the correlation between the aberration of the chromosome 13, rearrangement of IGH gene, translocations t(11;14) and t(4;14), the deletion of 17p13 and the prognostic factors in the patients with newly diagnosed MM who underwent autologous transplantation (AT) according protocol of CMG 2002 trial. Methods Fluorescence in situ hybridization and cytoplasm immunoglobulin staining (cIg-FISH) were used to detect monotypic plasma cells and aberrations mentioned above. Cytogenetic abnormalities were found in 70 newly diagnosed patients with MM, median of follow-up 17.5 months, median age 57 years (39-67), DS stadium: stage I 7.1%, II 24.3%, III 68.6%; A/B - 84.3%/15.7%. Results Overall response (OR) rate after AT was 78.5% including 13% CR, 27% VGPR and 38.5% PR. (en)
Title	ASSOCIATION BETWEEN CHROMOSOMAL CHANGES AND STANDARD PROGNOSTIC FACTORS IN PATIENTS WITH MULTIPLE MYELOMA UNDERGOING AUTOLOGOUS STEM CELL TRANSPLANTATION ASSOCIATION BETWEEN CHROMOSOMAL CHANGES AND STANDARD PROGNOSTIC FACTORS IN PATIENTS WITH MULTIPLE MYELOMA UNDERGOING AUTOLOGOUS STEM CELL TRANSPLANTATION (en)
skos:prefLabel	ASSOCIATION BETWEEN CHROMOSOMAL CHANGES AND STANDARD PROGNOSTIC FACTORS IN PATIENTS WITH MULTIPLE MYELOMA UNDERGOING AUTOLOGOUS STEM CELL TRANSPLANTATION ASSOCIATION BETWEEN CHROMOSOMAL CHANGES AND STANDARD PROGNOSTIC FACTORS IN PATIENTS WITH MULTIPLE MYELOMA UNDERGOING AUTOLOGOUS STEM CELL TRANSPLANTATION (en)
skos:notation	RIV/00216224:14110/07:00019110!RIV10-MZ0-14110___
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(NR8183)
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Pour, Luděk Kuglík, Petr Krejčí, Marta Hájek, Roman Adam, Zdeněk Filková, Hana Oltová, Alexandra Křivanová, Andrea Grešliková, Henrieta Smejkalová, Jana
http://linked.open.../riv/druhVysledku	D - Článek ve sborníku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Lékařská fakulta
http://linked.open...dnocenehoVysledku	410896
http://linked.open...ai/riv/idVysledku	RIV/00216224:14110/07:00019110
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Multiple Myeloma; cIg-FISH; 13q deletion; IGH rearrangement; 17p13 deletion (en)
http://linked.open.../riv/klicoveSlovo	13q deletion Multiple Myeloma 17p13 deletion IGH rearrangement cIg-FISH
http://linked.open...ontrolniKodProRIV	[81C61C5F953A]
http://linked.open...v/mistoKonaniAkce	Vienna, Austria
http://linked.open...i/riv/mistoVydani	Pavia, Italy
http://linked.open...i/riv/nazevZdroje	Hematologica/The Hematology Journal
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	10 (xsd:int)
http://linked.open...cetTvurcuVysledku	10 (xsd:int)
http://linked.open...vavai/riv/projekt	Molecular-cytogenetic analysis of marked plasma cells and prognostic significance of clonal chromosomal aberrations in multiple myeloma
http://linked.open...UplatneniVysledku	2007
http://linked.open...iv/tvurceVysledku	Adam, Zdeněk Hájek, Roman Krejčí, Marta Kuglík, Petr Pour, Luděk Filková, Hana Oltová, Alexandra Grešliková, Henrieta Křivanová, Andrea Smejkalová, Jana
http://linked.open...vavai/riv/typAkce	WRD - Světová
http://linked.open.../riv/zahajeniAkce	2007-06-07 (xsd:date)
issn	0390-6078
number of pages	1 (xsd:int)
http://purl.org/ne...btex#hasPublisher	Ferrata-Storti Foundation
http://localhost/t...ganizacniJednotka	14110

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