About: Association of miR-21, miR-31, miR-143, miR-145 and let-7a-1 levels with histopathologic features of colorectal cancer

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About: Association of miR-21, miR-31, miR-143, miR-145 and let-7a-1 levels with histopathologic features of colorectal cancer Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	RNAs, that repress protein translation through binding to target mRNAs. Although the number of verified human miRNA is still expanding, only few have been functionally described. However, emerging evidences suggest the involvement of altered regulation of miRNA in pathogenesis of cancers and these genes are thought to function as both tumours suppressor and oncogenes. Previous studies, mainly based on microarrays technology applied on colorectal cancer cell lines, showed altered expression levels of several miRNAs in colorectal cancer (CRC). MATERIALS AND METHODS: In our study, we examined by Real-Time PCR expression levels of miR-21, miR-31, miR-143, miR-145 and let-7a-1 in bioptic samples of 29 colorectal cancer patients including 3 cases of IUCC Stage I, 11 of Stage II, 6 of Stage III, 9 of Stage IV. For 6 cases of CRC samples also adjacent non-tumor tissues were analyzed. RNAs, that repress protein translation through binding to target mRNAs. Although the number of verified human miRNA is still expanding, only few have been functionally described. However, emerging evidences suggest the involvement of altered regulation of miRNA in pathogenesis of cancers and these genes are thought to function as both tumours suppressor and oncogenes. Previous studies, mainly based on microarrays technology applied on colorectal cancer cell lines, showed altered expression levels of several miRNAs in colorectal cancer (CRC). MATERIALS AND METHODS: In our study, we examined by Real-Time PCR expression levels of miR-21, miR-31, miR-143, miR-145 and let-7a-1 in bioptic samples of 29 colorectal cancer patients including 3 cases of IUCC Stage I, 11 of Stage II, 6 of Stage III, 9 of Stage IV. For 6 cases of CRC samples also adjacent non-tumor tissues were analyzed. (en)
Title	Association of miR-21, miR-31, miR-143, miR-145 and let-7a-1 levels with histopathologic features of colorectal cancer Association of miR-21, miR-31, miR-143, miR-145 and let-7a-1 levels with histopathologic features of colorectal cancer (en)
skos:prefLabel	Association of miR-21, miR-31, miR-143, miR-145 and let-7a-1 levels with histopathologic features of colorectal cancer Association of miR-21, miR-31, miR-143, miR-145 and let-7a-1 levels with histopathologic features of colorectal cancer (en)
skos:notation	RIV/00216224:14110/07:00019108!RIV10-MZ0-14110___
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(NR9076)
http://linked.open...iv/cisloPeriodika	4 (suppl.)
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Slabý, Ondřej Šachlová, Milana Garajová, Ingrid Svoboda, Miroslav Vyzula, Rostislav Svoboda, Marek Fabian, Pavel
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Lékařská fakulta
http://linked.open...dnocenehoVysledku	410905
http://linked.open...ai/riv/idVysledku	RIV/00216224:14110/07:00019108
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	colorectal cancer; microRNA; pathogenesis; metastasis (en)
http://linked.open.../riv/klicoveSlovo	colorectal cancer metastasis pathogenesis microRNA
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[8052C5DD672E]
http://linked.open...i/riv/nazevZdroje	European Journal of Cancer
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	7 (xsd:int)
http://linked.open...cetTvurcuVysledku	9 (xsd:int)
http://linked.open...vavai/riv/projekt	Gene expression profiling-based prediction of treatment response for patient with locally advanced rectal cancer treated by chemotherapy and radiotherapy
http://linked.open...UplatneniVysledku	2007
http://linked.open...v/svazekPeriodika	5
http://linked.open...iv/tvurceVysledku	Slabý, Ondřej Svoboda, Miroslav Šachlová, Milana Svoboda, Marek Vyzula, Rostislav Fabian, Pavel Knoflíčková, Dana Garajová, Ingrid Šmerdová, Tamara
issn	0959-8049
number of pages	2 (xsd:int)
http://localhost/t...ganizacniJednotka	14110

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