About: Transketolase (TKT) gene variability as a potencial susceptibility factor for diabetic nephropathy

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About: Transketolase (TKT) gene variability as a potencial susceptibility factor for diabetic nephropathy Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Objective: Accumulation of proximal glycolytic intermediates - due to the allosteric inhibition of enzymes, changed NADH/NAD+ ratio and modification of the glycolytic enzyme glyceraldehyd-3-phosphate dehydrogenase provides substrates for the metabolic pathways plays contributing to the pathogenesis of diabetic complications (such as formation of Advanced Glycation End-products (AGEs), polyols, hexosamines etc.). Pentose phosphate pathway (PPP) represents potentially %22protective%22 mechanism in hyperglycemia since shunting of cumulated glycolytic intermediates (esp. triosephosphates) into the PPP reactions supposedly %22disburdens%22 glycolysis and quantitatively limits processing of glycolytic intermediates in the alternative metabolic pathways. We hypothesized that genetic variability in the rate-limiting enzyme of the PPP non-oxidative branch - transketolase - contributes to an interindividual variability in the onset and progression of diabetic nephropathy (DN). Objective: Accumulation of proximal glycolytic intermediates - due to the allosteric inhibition of enzymes, changed NADH/NAD+ ratio and modification of the glycolytic enzyme glyceraldehyd-3-phosphate dehydrogenase provides substrates for the metabolic pathways plays contributing to the pathogenesis of diabetic complications (such as formation of Advanced Glycation End-products (AGEs), polyols, hexosamines etc.). Pentose phosphate pathway (PPP) represents potentially %22protective%22 mechanism in hyperglycemia since shunting of cumulated glycolytic intermediates (esp. triosephosphates) into the PPP reactions supposedly %22disburdens%22 glycolysis and quantitatively limits processing of glycolytic intermediates in the alternative metabolic pathways. We hypothesized that genetic variability in the rate-limiting enzyme of the PPP non-oxidative branch - transketolase - contributes to an interindividual variability in the onset and progression of diabetic nephropathy (DN). (en)
Title	Transketolase (TKT) gene variability as a potencial susceptibility factor for diabetic nephropathy Transketolase (TKT) gene variability as a potencial susceptibility factor for diabetic nephropathy (en)
skos:prefLabel	Transketolase (TKT) gene variability as a potencial susceptibility factor for diabetic nephropathy Transketolase (TKT) gene variability as a potencial susceptibility factor for diabetic nephropathy (en)
skos:notation	RIV/00216224:14110/07:00019057!RIV10-MZ0-14110___
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(NR9443)
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Pácal, Lukáš Dvořáková, Veronika Stejskalová, Andrea Kaňková, Kateřina
http://linked.open.../riv/druhVysledku	O - Ostatní výsledky nezařaditelné do žádného z výše uvedených druhů výsledku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Lékařská fakulta
http://linked.open...dnocenehoVysledku	455578
http://linked.open...ai/riv/idVysledku	RIV/00216224:14110/07:00019057
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	transketolase; polymorphism; diabetic nephropathy (en)
http://linked.open.../riv/klicoveSlovo	transketolase polymorphism diabetic nephropathy
http://linked.open...ontrolniKodProRIV	[61FE4658D6F4]
http://linked.open...in/vavai/riv/obor	FB
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	Genetic variability of pentose phosphate pathway as a modulating factor of the onset and progression of diabetic nephropathy
http://linked.open...UplatneniVysledku	2007
http://linked.open...iv/tvurceVysledku	Kaňková, Kateřina Pácal, Lukáš Tanhäuserová, Veronika Stejskalová, Andrea
http://localhost/t...ganizacniJednotka	14110

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