About: Raltitrexed plus oxaliplatin in the second-line treatment of metastatic colorectal cancer.     Goto   Sponge   NotDistinct   Permalink

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  • The primary endpoint of this study was to evaluate the efficacy (objective response rate; ORR) of combined chemotherapy with raltitrexed plus oxaliplatin as second-line treatment in patients with metastatic colorectal cancer (CRC). Secondary endpoints were overall survival (OS), time to progression (TTP) and toxicity (NCI-CTC criteria). The target population were patients with metastatic colorectal adenocarcinoma who progressed after first-line chemotherapy. Treatment consisted of raltitrexed 3 mg/m(2) as a 15-minute intravenous (IV) infusion followed 45 minutes later by oxaliplatin 130 mg/m(2) IV as a 2-h infusion on Day 1, repeated every 3 weeks until further disease progression (PD), unacceptable toxicity or the decision of the patient. A total of 51 patients, all with WHO performance status 0-2 received a median of 6 treatment cycles (range 1-11). After 3 cycles, 8 of the 47 evaluable patients (17%) had experienced an ORR, 28 patients (59.
  • The primary endpoint of this study was to evaluate the efficacy (objective response rate; ORR) of combined chemotherapy with raltitrexed plus oxaliplatin as second-line treatment in patients with metastatic colorectal cancer (CRC). Secondary endpoints were overall survival (OS), time to progression (TTP) and toxicity (NCI-CTC criteria). The target population were patients with metastatic colorectal adenocarcinoma who progressed after first-line chemotherapy. Treatment consisted of raltitrexed 3 mg/m(2) as a 15-minute intravenous (IV) infusion followed 45 minutes later by oxaliplatin 130 mg/m(2) IV as a 2-h infusion on Day 1, repeated every 3 weeks until further disease progression (PD), unacceptable toxicity or the decision of the patient. A total of 51 patients, all with WHO performance status 0-2 received a median of 6 treatment cycles (range 1-11). After 3 cycles, 8 of the 47 evaluable patients (17%) had experienced an ORR, 28 patients (59. (en)
Title
  • Raltitrexed plus oxaliplatin in the second-line treatment of metastatic colorectal cancer.
  • Raltitrexed plus oxaliplatin in the second-line treatment of metastatic colorectal cancer. (en)
skos:prefLabel
  • Raltitrexed plus oxaliplatin in the second-line treatment of metastatic colorectal cancer.
  • Raltitrexed plus oxaliplatin in the second-line treatment of metastatic colorectal cancer. (en)
skos:notation
  • RIV/00216224:14110/06:00039991!RIV10-MZ0-14110___
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • Z(MZ0MOU2005)
http://linked.open...iv/cisloPeriodika
  • 2
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 496379
http://linked.open...ai/riv/idVysledku
  • RIV/00216224:14110/06:00039991
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • colorectal cancer; palliative chemotherapy; raltitrexed oxaliplatin (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • SK - Slovenská republika
http://linked.open...ontrolniKodProRIV
  • [0D1413375900]
http://linked.open...i/riv/nazevZdroje
  • Neoplasma
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 53
http://linked.open...iv/tvurceVysledku
  • Dušek, Ladislav
  • Jarkovský, Jiří
  • Kiss, Igor
  • Demlová, Regina
  • Vyzula, Rostislav
  • Kocáková, Ilona
http://linked.open...n/vavai/riv/zamer
issn
  • 0028-2685
number of pages
http://localhost/t...ganizacniJednotka
  • 14110
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