About: Gene expression of the phenylethanolamine N-methyltransferase is differently modulated in cardiac atria and ventricles     Goto   Sponge   NotDistinct   Permalink

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Description
  • Phenylethanolamine N-methyltransferase (PNMT) is a final enzyme in catecholamine synthesizing cascade that converts noradrenaline to adrenaline. Although most profuse in adrenal medulla, PNMT is expressed also in the heart, particularly in cardiac atria and ventricles. In atria, the PNMT mRNA is much more abundant compared to ventricles. In this work we aimed to find out, whether there is difference in modulation of the PNMT gene expression in cardiac atria and ventricles. We used three methodological approaches - cold as a model of mild stress, hypoxia as a model of cardiac ischemic injury and transgenic rats with incorporated mouse renin gene [TGR (mREN-2)27], to determine involvement of renin-angiotensin pathway in the PNMT gene expression. We have found that PNMT gene expression was modulated differently in cardiac atria and ventricles. In atria PNMT mRNA levels were increased by hypoxia, while cold stress decreased PNMT mRNA levels.
  • Phenylethanolamine N-methyltransferase (PNMT) is a final enzyme in catecholamine synthesizing cascade that converts noradrenaline to adrenaline. Although most profuse in adrenal medulla, PNMT is expressed also in the heart, particularly in cardiac atria and ventricles. In atria, the PNMT mRNA is much more abundant compared to ventricles. In this work we aimed to find out, whether there is difference in modulation of the PNMT gene expression in cardiac atria and ventricles. We used three methodological approaches - cold as a model of mild stress, hypoxia as a model of cardiac ischemic injury and transgenic rats with incorporated mouse renin gene [TGR (mREN-2)27], to determine involvement of renin-angiotensin pathway in the PNMT gene expression. We have found that PNMT gene expression was modulated differently in cardiac atria and ventricles. In atria PNMT mRNA levels were increased by hypoxia, while cold stress decreased PNMT mRNA levels. (en)
Title
  • Gene expression of the phenylethanolamine N-methyltransferase is differently modulated in cardiac atria and ventricles
  • Gene expression of the phenylethanolamine N-methyltransferase is differently modulated in cardiac atria and ventricles (en)
skos:prefLabel
  • Gene expression of the phenylethanolamine N-methyltransferase is differently modulated in cardiac atria and ventricles
  • Gene expression of the phenylethanolamine N-methyltransferase is differently modulated in cardiac atria and ventricles (en)
skos:notation
  • RIV/00216224:14110/06:00031735!RIV10-MSM-14110___
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • S
http://linked.open...iv/cisloPeriodika
  • 4
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 476761
http://linked.open...ai/riv/idVysledku
  • RIV/00216224:14110/06:00031735
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • PNMT; cardiac atria; cardiac ventricles; hypoxia; cold stress; renin (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • SK - Slovenská republika
http://linked.open...ontrolniKodProRIV
  • [811F8D8B58E3]
http://linked.open...i/riv/nazevZdroje
  • General Physiology and Biophysics
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 25
http://linked.open...iv/tvurceVysledku
  • Nováková, Marie
  • Zeman, Michal
  • Kopáček, J.
  • Križanová, Olga
  • Tillinger, Andrej
  • Bruderová, V.
  • Kubovčáková, Lucie
  • Květňanský, Richard
http://linked.open...ain/vavai/riv/wos
  • 000244957800002
issn
  • 0231-5882
number of pages
http://localhost/t...ganizacniJednotka
  • 14110
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