About: The influence of gender on metabolic activity of enzymatic system of cytochrome P450 in the model of isolated perfused rat liver.

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About: The influence of gender on metabolic activity of enzymatic system of cytochrome P450 in the model of isolated perfused rat liver. Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Interindividual variability of activity of oxidative and conjugating enzymes, especially the system of cytochrome P450, can be based on many different factors i.e. gender, age, genetic factors or interactions between simultaneously applied drugs. Such a variability may result in a different pharmacoterapeutical effectivity, adverse effects or toxicity of apllied drug. A suitable model for investigations on the activity of hepatic CYPs 450 and biotransformation processes is represented by the isolated perfused liver. As we expected, the activity of CYP subfamilies differed due to gender. CYP 2D2 activity in rat females was significantly higher than in males (Fig. 1). Also the final concentration of a marker metabolite (dextrorphan) in females was higher only in CYP 2D2. The elevation was 5,7% in the 30th min, 33% in the 60th min and 34% in the 120th min. In contrast activity in CYP 3A subfamily in females was lower than in males. Interindividual variability of activity of oxidative and conjugating enzymes, especially the system of cytochrome P450, can be based on many different factors i.e. gender, age, genetic factors or interactions between simultaneously applied drugs. Such a variability may result in a different pharmacoterapeutical effectivity, adverse effects or toxicity of apllied drug. A suitable model for investigations on the activity of hepatic CYPs 450 and biotransformation processes is represented by the isolated perfused liver. As we expected, the activity of CYP subfamilies differed due to gender. CYP 2D2 activity in rat females was significantly higher than in males (Fig. 1). Also the final concentration of a marker metabolite (dextrorphan) in females was higher only in CYP 2D2. The elevation was 5,7% in the 30th min, 33% in the 60th min and 34% in the 120th min. In contrast activity in CYP 3A subfamily in females was lower than in males. (en)
Title	The influence of gender on metabolic activity of enzymatic system of cytochrome P450 in the model of isolated perfused rat liver. The influence of gender on metabolic activity of enzymatic system of cytochrome P450 in the model of isolated perfused rat liver. (en)
skos:prefLabel	The influence of gender on metabolic activity of enzymatic system of cytochrome P450 in the model of isolated perfused rat liver. The influence of gender on metabolic activity of enzymatic system of cytochrome P450 in the model of isolated perfused rat liver. (en)
skos:notation	RIV/00216224:14110/06:00017778!RIV10-MSM-14110___
http://linked.open...avai/riv/aktivita	Z
http://linked.open...avai/riv/aktivity	Z(MSM0021622404)
http://linked.open...iv/cisloPeriodika	3
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Juřica, Jan Zendulka, Ondřej Zahradníková, Lucia McCaskey Hadašová, Eva Dostálek, Miroslav
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Lékařská fakulta
http://linked.open...dnocenehoVysledku	479396
http://linked.open...ai/riv/idVysledku	RIV/00216224:14110/06:00017778
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	cytochrome P450; the isolated perfused liver; influence of gender (en)
http://linked.open.../riv/klicoveSlovo	cytochrome P450 the isolated perfused liver influence of gender
http://linked.open...odStatuVydavatele	IT - Italská republika
http://linked.open...ontrolniKodProRIV	[695CC14AB0AE]
http://linked.open...i/riv/nazevZdroje	Homeostasis in Health and Diseases
http://linked.open...in/vavai/riv/obor	FR
http://linked.open...ichTvurcuVysledku	5 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...UplatneniVysledku	2006
http://linked.open...v/svazekPeriodika	44
http://linked.open...iv/tvurceVysledku	Dostálek, Miroslav Juřica, Jan Zendulka, Ondřej Zahradníková, Lucia McCaskey Hadašová, Eva
http://linked.open...n/vavai/riv/zamer	The Internal Organisation and Neurobiological Mechanisms of Functional CNS Systems under Normal and Pathological Conditions
issn	0960-7560
number of pages	3 (xsd:int)
http://localhost/t...ganizacniJednotka	14110

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