About: Behavioural and immune effects of cannabidiol in a mouse model of bilateral olfactory bulbectomy     Goto   Sponge   NotDistinct   Permalink

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Description
  • The study tested an antidepressant effect of cannabidiol (CBD) in olfactory bulbectomized (OB) mice, a well-established animal model of depression resembling behavioural, immune and endocrine changes. CBD did not show antidepressant behavioural properties in this animal model. This can discussed in relation to our previous results in social defeat mouse model, where CBD appeared to elicit anxiolytic activity. Reversal of the suppressed leukocyte phagocytosis in the OB mice by CBD correlates with the stimulatory effect of cannabinoids reffered in the literature.
  • The study tested an antidepressant effect of cannabidiol (CBD) in olfactory bulbectomized (OB) mice, a well-established animal model of depression resembling behavioural, immune and endocrine changes. CBD did not show antidepressant behavioural properties in this animal model. This can discussed in relation to our previous results in social defeat mouse model, where CBD appeared to elicit anxiolytic activity. Reversal of the suppressed leukocyte phagocytosis in the OB mice by CBD correlates with the stimulatory effect of cannabinoids reffered in the literature. (en)
  • Sledovány byly behaviorální a imunitní účinky kanabidiolu v myším modelu deprese - bilaterální olfaktorické bulbektomie. Behaviorální antidepresivní účinky kanabidiolu nebyly jednoznačně prokázány. Kanabidiol normalizoval potlačenou leukocytární fagocytózu v použitém zvířecím modelu deprese. (cs)
Title
  • Behavioural and immune effects of cannabidiol in a mouse model of bilateral olfactory bulbectomy
  • Behaviorální a imunitní účinky kanabidiolu v myším modelu bilaterální olfaktorické bulbektomie (cs)
  • Behavioural and immune effects of cannabidiol in a mouse model of bilateral olfactory bulbectomy (en)
skos:prefLabel
  • Behavioural and immune effects of cannabidiol in a mouse model of bilateral olfactory bulbectomy
  • Behaviorální a imunitní účinky kanabidiolu v myším modelu bilaterální olfaktorické bulbektomie (cs)
  • Behavioural and immune effects of cannabidiol in a mouse model of bilateral olfactory bulbectomy (en)
skos:notation
  • RIV/00216224:14110/06:00017758!RIV08-MSM-14110___
http://linked.open.../vavai/riv/strany
  • 778
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • Z(MSM 141100001), Z(MSM0021622404)
http://linked.open...iv/cisloPeriodika
  • 12
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 466694
http://linked.open...ai/riv/idVysledku
  • RIV/00216224:14110/06:00017758
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • cannabidiol; mice; depression; olfactory bulbectomy (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • US - Spojené státy americké
http://linked.open...ontrolniKodProRIV
  • [18944126CA30]
http://linked.open...i/riv/nazevZdroje
  • The International Journal of Neuropsychopharmacology
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 9
http://linked.open...iv/tvurceVysledku
  • Šulcová, Alexandra
  • Pistovčáková, Jana
  • Kelly, John
  • Leonard, Brian
http://linked.open...n/vavai/riv/zamer
issn
  • 1461-1457
number of pages
http://localhost/t...ganizacniJednotka
  • 14110
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