About: Serum matrix metalloproteinase (MMP-2) and its tissue inhibitor (TIMP-1) in relation to pro- and anti-fibrotic factors in patients with heart failure     Goto   Sponge   NotDistinct   Permalink

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  • Matrix metalloproteinase MMP-2 and its endogenous inhibitor TIMP-1 are associated with extracellular matrix remodeling, which may lead to interstitial fibrosis and thus contribute to heart failure. Besides, pro- and anti-fibrotic factors such as endothelin-1 and nitric oxide, respectively, regulate fibrosis by modulating collagen synthesis and also MMP/TIMP activity. Nowadays, there is thought that progressive remodeling accompanied with changes in the extracellular matrix may lead to severe heart failure. The aim of this study was to find a relationship between MMP-2/TIMP-1 and other above mentioned parameters in patients with heart failure.
  • Matrix metalloproteinase MMP-2 and its endogenous inhibitor TIMP-1 are associated with extracellular matrix remodeling, which may lead to interstitial fibrosis and thus contribute to heart failure. Besides, pro- and anti-fibrotic factors such as endothelin-1 and nitric oxide, respectively, regulate fibrosis by modulating collagen synthesis and also MMP/TIMP activity. Nowadays, there is thought that progressive remodeling accompanied with changes in the extracellular matrix may lead to severe heart failure. The aim of this study was to find a relationship between MMP-2/TIMP-1 and other above mentioned parameters in patients with heart failure. (en)
Title
  • Serum matrix metalloproteinase (MMP-2) and its tissue inhibitor (TIMP-1) in relation to pro- and anti-fibrotic factors in patients with heart failure
  • Serum matrix metalloproteinase (MMP-2) and its tissue inhibitor (TIMP-1) in relation to pro- and anti-fibrotic factors in patients with heart failure (en)
skos:prefLabel
  • Serum matrix metalloproteinase (MMP-2) and its tissue inhibitor (TIMP-1) in relation to pro- and anti-fibrotic factors in patients with heart failure
  • Serum matrix metalloproteinase (MMP-2) and its tissue inhibitor (TIMP-1) in relation to pro- and anti-fibrotic factors in patients with heart failure (en)
skos:notation
  • RIV/00216224:14110/06:00017183!RIV10-MSM-14110___
http://linked.open...avai/riv/aktivita
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  • Z(MSM0021622402)
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  • 499012
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  • RIV/00216224:14110/06:00017183
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  • metalloproteinase - tissue inhibitor - fibrotic factors - heart failure (en)
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  • [3E2EDCE49F26]
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  • Piešťany, Slovak Republic
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  • Bratislava
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  • Proceedings from XX. Biochemický zjazd
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  • Tomandl, Josef
  • Táborská, Eva
  • Špinar, Jindřich
  • Špinarová, Lenka
  • Paulová, Hana
http://linked.open...vavai/riv/typAkce
http://linked.open.../riv/zahajeniAkce
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number of pages
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  • Ústav molekulárnej fyziológie a genetiky SAV
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  • 80-969532-6-5
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  • 14110
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