About: Molekulární charakterizace progredujícího metastatického kolorektalního karcinomu pomocí oligonukleotidových makročipů

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About: Molekulární charakterizace progredujícího metastatického kolorektalního karcinomu pomocí oligonukleotidových makročipů Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	PURPOSE: Colorectal cancer (CRC) is one of the most common malignancies. Unfortunately a significant proportion of surgically cured patiens in the early stage of the disease develop progression and die from the disease. This study aimed to find individual up/down-regulated genes associated with progression and metastatic potential of colorectal cancers using low-density oligonucleotide microarrays. Molecular characterization of patients at high risk of cancer progression may assist to oncologists in treatment decision by selecting those patients who will need adjuvant chemotherapy. PATIENTS AND METHODS: Patients who underwent surgical resection were divided into different prognostic groups by disease-free survival (DFS>36 month – good prognosis; DFS<36 month – bad prognosis). Total RNA was extracted from each frozen tumor specimen and gene expression profiles were obtained using a human oligonucleotide microrray (SuperArray) spotted with 128 genes known to be involved in metastasis. Genes with e PURPOSE: Colorectal cancer (CRC) is one of the most common malignancies. Unfortunately a significant proportion of surgically cured patiens in the early stage of the disease develop progression and die from the disease. This study aimed to find individual up/down-regulated genes associated with progression and metastatic potential of colorectal cancers using low-density oligonucleotide microarrays. Molecular characterization of patients at high risk of cancer progression may assist to oncologists in treatment decision by selecting those patients who will need adjuvant chemotherapy. PATIENTS AND METHODS: Patients who underwent surgical resection were divided into different prognostic groups by disease-free survival (DFS>36 month – good prognosis; DFS<36 month – bad prognosis). Total RNA was extracted from each frozen tumor specimen and gene expression profiles were obtained using a human oligonucleotide microrray (SuperArray) spotted with 128 genes known to be involved in metastasis. Genes with e (en) PURPOSE: Colorectal cancer (CRC) is one of the most common malignancies. Unfortunately a significant proportion of surgically cured patiens in the early stage of the disease develop progression and die from the disease. This study aimed to find individual up/down-regulated genes associated with progression and metastatic potential of colorectal cancers using low-density oligonucleotide microarrays. Molecular characterization of patients at high risk of cancer progression may assist to oncologists in treatment decision by selecting those patients who will need adjuvant chemotherapy. PATIENTS AND METHODS: Patients who underwent surgical resection were divided into different prognostic groups by disease-free survival (DFS>36 month – good prognosis; DFS<36 month – bad prognosis). Total RNA was extracted from each frozen tumor specimen and gene expression profiles were obtained using a human oligonucleotide microrray (SuperArray) spotted with 128 genes known to be involved in metastasis. Genes with e (cs)
Title	Molekulární charakterizace progredujícího metastatického kolorektalního karcinomu pomocí oligonukleotidových makročipů Molecular characterization of primary colorectal cancers with progressive metastatic phenotype by oligonucleotide microarrays (en) Molekulární charakterizace progredujícího metastatického kolorektalního karcinomu pomocí oligonukleotidových makročipů (cs)
skos:prefLabel	Molekulární charakterizace progredujícího metastatického kolorektalního karcinomu pomocí oligonukleotidových makročipů Molecular characterization of primary colorectal cancers with progressive metastatic phenotype by oligonucleotide microarrays (en) Molekulární charakterizace progredujícího metastatického kolorektalního karcinomu pomocí oligonukleotidových makročipů (cs)
skos:notation	RIV/00216224:14110/06:00017176!RIV07-MSM-14110___
http://linked.open.../vavai/riv/strany	213
http://linked.open...avai/riv/aktivita	S
http://linked.open...avai/riv/aktivity	S
http://linked.open...vai/riv/dodaniDat	2007
http://linked.open...aciTvurceVysledku	Slabý, Ondřej Garajová, Ingrid Svoboda, Miroslav Vyzula, Rostislav Svoboda, Marek
http://linked.open.../riv/druhVysledku	D - Článek ve sborníku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Lékařská fakulta
http://linked.open...dnocenehoVysledku	486651
http://linked.open...ai/riv/idVysledku	RIV/00216224:14110/06:00017176
http://linked.open...riv/jazykVysledku	cze - čeština
http://linked.open.../riv/klicovaSlova	colorectal cancer; DNA microarray technology; gene expression; pathogenesis; prognosis; prediction (en)
http://linked.open.../riv/klicoveSlovo	gene expression colorectal cancer pathogenesis prediction prognosis DNA microarray technology
http://linked.open...ontrolniKodProRIV	[A73C76AEFD92]
http://linked.open...v/mistoKonaniAkce	Piešťany
http://linked.open...i/riv/mistoVydani	Piešťany
http://linked.open...i/riv/nazevZdroje	sborník XX. BIOCHEMICKÝ ZJAZD
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	5 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...UplatneniVysledku	2006
http://linked.open...iv/tvurceVysledku	Slabý, Ondřej Svoboda, Miroslav Svoboda, Marek Vyzula, Rostislav Garajová, Ingrid
http://linked.open...vavai/riv/typAkce	EUR - Evropská
http://linked.open.../riv/zahajeniAkce	2006-01-01 (xsd:date)
number of pages	1 (xsd:int)
http://purl.org/ne...btex#hasPublisher	Slovenská spoločnosť pre biochémiu a molekulárnu biológiu pri SAV
https://schema.org/isbn	80-969532-6-5
http://localhost/t...ganizacniJednotka	14110

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