About: Embryonic stem cell-derived microvesicles reprogram hematopoietic progenitors: evidence for horizontal transfer of mRNA and protein delivery

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About: Embryonic stem cell-derived microvesicles reprogram hematopoietic progenitors: evidence for horizontal transfer of mRNA and protein delivery Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Membrane-derived microvesicles (MV) are released from the surface of activated eukaryotic cells and exert pleiotropic effects on surrounding cells. We found that MV derived from embryonic stem cells enhanced survival and improved expansion of murine hematopoietic stem cells, upregulated the expression of early pluripotent (Oct-4, Nanog, Rex-1) and early hematopoietic stem cell (Scl, HoxB4, GATA 2) markers in these cells, and induced phosphorylation of MAPK and Akt. We postulate that embryonic stem cell-derived MVs may efficiently expand hematopoietic stem cells by stimulating them with MV expressed ligands as well as increase their pluripotency after horizontal transfer of mRNA. Membrane-derived microvesicles (MV) are released from the surface of activated eukaryotic cells and exert pleiotropic effects on surrounding cells. We found that MV derived from embryonic stem cells enhanced survival and improved expansion of murine hematopoietic stem cells, upregulated the expression of early pluripotent (Oct-4, Nanog, Rex-1) and early hematopoietic stem cell (Scl, HoxB4, GATA 2) markers in these cells, and induced phosphorylation of MAPK and Akt. We postulate that embryonic stem cell-derived MVs may efficiently expand hematopoietic stem cells by stimulating them with MV expressed ligands as well as increase their pluripotency after horizontal transfer of mRNA. (en)
Title	Embryonic stem cell-derived microvesicles reprogram hematopoietic progenitors: evidence for horizontal transfer of mRNA and protein delivery Embryonic stem cell-derived microvesicles reprogram hematopoietic progenitors: evidence for horizontal transfer of mRNA and protein delivery (en)
skos:prefLabel	Embryonic stem cell-derived microvesicles reprogram hematopoietic progenitors: evidence for horizontal transfer of mRNA and protein delivery Embryonic stem cell-derived microvesicles reprogram hematopoietic progenitors: evidence for horizontal transfer of mRNA and protein delivery (en)
skos:notation	RIV/00216224:14110/06:00016633!RIV10-GA0-14110___
http://linked.open...avai/riv/aktivita	P S Z
http://linked.open...avai/riv/aktivity	P(GA301/03/1122), P(LC06077), S, Z(AV0Z50390512)
http://linked.open...iv/cisloPeriodika	5
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Dvořák, Petr
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Lékařská fakulta
http://linked.open...dnocenehoVysledku	473999
http://linked.open...ai/riv/idVysledku	RIV/00216224:14110/06:00016633
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	microvesicles; embryonic stem cells; stem cell expansion; mRNA transfer; Oct-4 (en)
http://linked.open.../riv/klicoveSlovo	embryonic stem cells Oct-4 mRNA transfer microvesicles stem cell expansion
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[F860C7B95380]
http://linked.open...i/riv/nazevZdroje	Leukemia
http://linked.open...in/vavai/riv/obor	ED
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...vavai/riv/projekt	FGF-2 and FGFR-3 in chronic myeloid leukemia. A study on model leukemia cell lines and on CD34+ progenitor cells from patients Center of Chemical Genetics
http://linked.open...UplatneniVysledku	2006
http://linked.open...v/svazekPeriodika	20
http://linked.open...iv/tvurceVysledku	Dvořák, Petr Zhang, J. Kucia, M. Miekus, K. Ratajczak, J. Ratajczak, M. Z. Reca, R.
http://linked.open...ain/vavai/riv/wos	000237239400014
http://linked.open...n/vavai/riv/zamer	Molekulární, buněčné a systémové mechanizmy závažných onemocnění lidského organizmu, jejich diagnostika, terapie a farmakoterapie
issn	0887-6924
number of pages	3 (xsd:int)
http://localhost/t...ganizacniJednotka	14110

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