About: The functional role of cardiac T-tubules in a model of rat ventricular myocytes

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About: The functional role of cardiac T-tubules in a model of rat ventricular myocytes Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The morphology of the cardiac transverse axial tubular system (TATS) has been known for decades, but its function has received little attention. To explore the possible role of this system in the physiological modulation of electrical and contractile activity, we have developed a mathematical model of rat ventricular cardiomyocytes in which the TATS is described as a single compartment. In the model, the action potentials initiated in current clamp mode were accompanied by transient K+ accumulation and transient Ca2+ depletion in the TATS lumen. The amplitude of these changes relative to external ion concentrations was studied at steady state stimulation frequencies of 1 to 5 Hz. Ca2+ depletion increased from 7 % to 13.1 % with stimulation frequency, while K+ accumulation decreased from 4.1 % to 2.7 %. These ionic changes (particularly Ca2+ depletion) implicated significant decrease of intracellular Ca2+ load at frequencies natural for rat heart. The morphology of the cardiac transverse axial tubular system (TATS) has been known for decades, but its function has received little attention. To explore the possible role of this system in the physiological modulation of electrical and contractile activity, we have developed a mathematical model of rat ventricular cardiomyocytes in which the TATS is described as a single compartment. In the model, the action potentials initiated in current clamp mode were accompanied by transient K+ accumulation and transient Ca2+ depletion in the TATS lumen. The amplitude of these changes relative to external ion concentrations was studied at steady state stimulation frequencies of 1 to 5 Hz. Ca2+ depletion increased from 7 % to 13.1 % with stimulation frequency, while K+ accumulation decreased from 4.1 % to 2.7 %. These ionic changes (particularly Ca2+ depletion) implicated significant decrease of intracellular Ca2+ load at frequencies natural for rat heart. (en)
Title	The functional role of cardiac T-tubules in a model of rat ventricular myocytes The functional role of cardiac T-tubules in a model of rat ventricular myocytes (en)
skos:prefLabel	The functional role of cardiac T-tubules in a model of rat ventricular myocytes The functional role of cardiac T-tubules in a model of rat ventricular myocytes (en)
skos:notation	RIV/00216224:14110/06:00015542!RIV10-MSM-14110___
http://linked.open...avai/riv/aktivita	Z
http://linked.open...avai/riv/aktivity	Z(AV0Z20760514), Z(MSM0021622402)
http://linked.open...iv/cisloPeriodika	1842
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Pásek, Michal Šimurda, Jiří
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Lékařská fakulta
http://linked.open...dnocenehoVysledku	476472
http://linked.open...ai/riv/idVysledku	RIV/00216224:14110/06:00015542
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	accumulation-depletion of ions; transverse tubule; heart; mathematical model; cardiomyocyte; rat (en)
http://linked.open.../riv/klicoveSlovo	mathematical model accumulation-depletion of ions transverse tubule rat heart cardiomyocyte
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[7795B887EE7E]
http://linked.open...i/riv/nazevZdroje	Philosophical Transactions of the Royal Society
http://linked.open...in/vavai/riv/obor	BO
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	3 (xsd:int)
http://linked.open...UplatneniVysledku	2006
http://linked.open...v/svazekPeriodika	364
http://linked.open...iv/tvurceVysledku	Pásek, Michal Šimurda, Jiří Christé, Georges
http://linked.open...ain/vavai/riv/wos	000237189500006
http://linked.open...n/vavai/riv/zamer	Complex dynamical systems in thermodynamics, fluid and solid mechanics Early diagnostics and treatment of cardiovascular diseases
issn	1364-503X
number of pages	20 (xsd:int)
http://localhost/t...ganizacniJednotka	14110

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