About: The Effect Of Perphenazine On Transient Outward Potassium Current In Rat Ventricular Myocytes

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The aim of this study was to explore the effect of a phenothiazine neuroleptic drug perphenazine on transient outward potassium current Ito in rat ventricular myocytes. Perphenazine reversibly decreased the amplitude and accelerated the apparent inactivation of Ito in a concentration-dependent manner with EC50 = 26.4 +/- 3.5 umol/l and Hill coefficient n = 0.84 +/- 0.10 (evaluated from changes of time integral of Ito). Time course of Ito-inactivation was well fitted by a double exponential function; the fast time constant tf was significantly decreased under the effect of perphenazine and its concentration dependence was comparable with the concentration dependence of Ito-block represented by time integrals (EC50 = 26.8 +/- 8.2 umol/l, n = 0.88 +/- 0.28). It is suggested that perphenazine-induced block via open channel is very likely involved in the mechanism of drug-channel interaction. The aim of this study was to explore the effect of a phenothiazine neuroleptic drug perphenazine on transient outward potassium current Ito in rat ventricular myocytes. Perphenazine reversibly decreased the amplitude and accelerated the apparent inactivation of Ito in a concentration-dependent manner with EC50 = 26.4 +/- 3.5 umol/l and Hill coefficient n = 0.84 +/- 0.10 (evaluated from changes of time integral of Ito). Time course of Ito-inactivation was well fitted by a double exponential function; the fast time constant tf was significantly decreased under the effect of perphenazine and its concentration dependence was comparable with the concentration dependence of Ito-block represented by time integrals (EC50 = 26.8 +/- 8.2 umol/l, n = 0.88 +/- 0.28). It is suggested that perphenazine-induced block via open channel is very likely involved in the mechanism of drug-channel interaction. (en)
Title	The Effect Of Perphenazine On Transient Outward Potassium Current In Rat Ventricular Myocytes The Effect Of Perphenazine On Transient Outward Potassium Current In Rat Ventricular Myocytes (en)
skos:prefLabel	The Effect Of Perphenazine On Transient Outward Potassium Current In Rat Ventricular Myocytes The Effect Of Perphenazine On Transient Outward Potassium Current In Rat Ventricular Myocytes (en)
skos:notation	RIV/00216224:14110/06:00015373!RIV10-GA0-14110___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA305/04/1385), Z(AV0Z20760514), Z(MSM0021622402)
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Matejovič, Peter Bébarová, Markéta Nováková, Marie Pásek, Michal Šimurda, Jiří Šimurdová, Milena
http://linked.open.../riv/druhVysledku	D - Článek ve sborníku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Lékařská fakulta
http://linked.open...dnocenehoVysledku	473157
http://linked.open...ai/riv/idVysledku	RIV/00216224:14110/06:00015373
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	rat ventricular myocyte; transient outward current; perphenazine (en)
http://linked.open.../riv/klicoveSlovo	transient outward current perphenazine rat ventricular myocyte
http://linked.open...ontrolniKodProRIV	[DDAD48B7B08B]
http://linked.open...v/mistoKonaniAkce	Brno
http://linked.open...i/riv/mistoVydani	Brno
http://linked.open...i/riv/nazevZdroje	Analysis of Biomedical Signals and Images
http://linked.open...in/vavai/riv/obor	ED
http://linked.open...ichTvurcuVysledku	6 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...vavai/riv/projekt	Modulatory role of sigma signalling in electromechanical coupling of isolated cardiomyocyte and heart
http://linked.open...UplatneniVysledku	2006
http://linked.open...iv/tvurceVysledku	Bébarová, Markéta Pásek, Michal Šimurda, Jiří Nováková, Marie Šimurdová, Milena Matejovič, Peter Račkauskas, G.
http://linked.open...vavai/riv/typAkce	WRD - Světová
http://linked.open.../riv/zahajeniAkce	2006-06-28 (xsd:date)
http://linked.open...n/vavai/riv/zamer	Complex dynamical systems in thermodynamics, fluid and solid mechanics Early diagnostics and treatment of cardiovascular diseases
number of pages	3 (xsd:int)
http://purl.org/ne...btex#hasPublisher	Vysoké učení technické v Brně. Nakladatelství VUTIUM
https://schema.org/isbn	80-214-3152-0
http://localhost/t...ganizacniJednotka	14110

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