About: Effect of Ajmaline on Action Potential and Ionic Currents in Rat Ventricular Myocytes with Focus on Transient Outward Current

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About: Effect of Ajmaline on Action Potential and Ionic Currents in Rat Ventricular Myocytes with Focus on Transient Outward Current Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	We conclude that ajmaline is a potent blocker of IK(ATP), INa and Ito. In rat ventricular myocytes, block of INa is responsible for the decrease in upstroke velocity and the decline in AP amplitude. The main determinant of AP prolongation is block of Ito. Ajmaline is an open state blocker of Ito with fast recovery kinetics manifested in frequency independence of block. We conclude that ajmaline is a potent blocker of IK(ATP), INa and Ito. In rat ventricular myocytes, block of INa is responsible for the decrease in upstroke velocity and the decline in AP amplitude. The main determinant of AP prolongation is block of Ito. Ajmaline is an open state blocker of Ito with fast recovery kinetics manifested in frequency independence of block. (en)
Title	Effect of Ajmaline on Action Potential and Ionic Currents in Rat Ventricular Myocytes with Focus on Transient Outward Current Effect of Ajmaline on Action Potential and Ionic Currents in Rat Ventricular Myocytes with Focus on Transient Outward Current (en)
skos:prefLabel	Effect of Ajmaline on Action Potential and Ionic Currents in Rat Ventricular Myocytes with Focus on Transient Outward Current Effect of Ajmaline on Action Potential and Ionic Currents in Rat Ventricular Myocytes with Focus on Transient Outward Current (en)
skos:notation	RIV/00216224:14110/05:00047843!RIV11-MSM-14110___
http://linked.open...avai/riv/aktivita	Z
http://linked.open...avai/riv/aktivity	Z(MSM0021622402)
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Matejovič, Peter Bébarová, Markéta Šimurda, Jiří Šimurdová, Milena
http://linked.open.../riv/druhVysledku	O - Ostatní výsledky nezařaditelné do žádného z výše uvedených druhů výsledku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Lékařská fakulta
http://linked.open...dnocenehoVysledku	519234
http://linked.open...ai/riv/idVysledku	RIV/00216224:14110/05:00047843
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	ajmaline; ionic current; transient outward potassium current; rat cardiomyocytes (en)
http://linked.open.../riv/klicoveSlovo	transient outward potassium current ionic current ajmaline rat cardiomyocytes
http://linked.open...ontrolniKodProRIV	[BFB5FC4CD008]
http://linked.open...in/vavai/riv/obor	ED
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...UplatneniVysledku	2005
http://linked.open...iv/tvurceVysledku	Bébarová, Markéta Pásek, Michal Šimurda, Jiří Šimurdová, Milena Matejovič, Peter
http://linked.open...n/vavai/riv/zamer	Early diagnostics and treatment of cardiovascular diseases
http://localhost/t...ganizacniJednotka	14110

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