About: Prognostic factors for survival after autologous transplantation: a single centre experience in 133 multiple myeloma patients.

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About: Prognostic factors for survival after autologous transplantation: a single centre experience in 133 multiple myeloma patients. Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Autologous stem cell transplantation (ASCT) has an established role in the treatment of symptomatic multiple myeloma (MM). Our aim was to analyse the impact of selected prognostic parameters on the survival of patients with MM after ASCT. The new International Staging System (ISS) was also evaluated. A total of 133 MM patients were transplanted in our centre between 1995 and 2002. Following ASCT, 35% of patients were in complete remission (CR) and 60% were in partial remission (PR). The median progression-free (PFS) and overall (OS) survival from transplantation were 29.5 and 68.8 months, respectively. Transplant-related mortality (TRM) was 3%. On multivariate analysis, factors associated with significantly shorter OS were lack of CR after transplant (P = 0.002, hazard ratio (HR): 3.1), stage 3 according to ISS (P = 0.001, HR: 3.0) and age at transplant over 60 years (P = 0.035, HR: 2.0). The status of disease before ASCT did not significantly affect PFS and OS after transplantation. Autologous stem cell transplantation (ASCT) has an established role in the treatment of symptomatic multiple myeloma (MM). Our aim was to analyse the impact of selected prognostic parameters on the survival of patients with MM after ASCT. The new International Staging System (ISS) was also evaluated. A total of 133 MM patients were transplanted in our centre between 1995 and 2002. Following ASCT, 35% of patients were in complete remission (CR) and 60% were in partial remission (PR). The median progression-free (PFS) and overall (OS) survival from transplantation were 29.5 and 68.8 months, respectively. Transplant-related mortality (TRM) was 3%. On multivariate analysis, factors associated with significantly shorter OS were lack of CR after transplant (P = 0.002, hazard ratio (HR): 3.1), stage 3 according to ISS (P = 0.001, HR: 3.0) and age at transplant over 60 years (P = 0.035, HR: 2.0). The status of disease before ASCT did not significantly affect PFS and OS after transplantation. (en)
Title	Prognostic factors for survival after autologous transplantation: a single centre experience in 133 multiple myeloma patients. Prognostic factors for survival after autologous transplantation: a single centre experience in 133 multiple myeloma patients. (en)
skos:prefLabel	Prognostic factors for survival after autologous transplantation: a single centre experience in 133 multiple myeloma patients. Prognostic factors for survival after autologous transplantation: a single centre experience in 133 multiple myeloma patients. (en)
skos:notation	RIV/00216224:14110/05:00035910!RIV10-MSM-14110___
http://linked.open...avai/riv/aktivita	V
http://linked.open...avai/riv/aktivity	V
http://linked.open...iv/cisloPeriodika	2
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Pour, Luděk Vorlíček, Jiří Büchler, Tomáš Mayer, Jiří Krejčí, Marta Hájek, Roman Adam, Zdeněk Křivanová, Andrea
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Lékařská fakulta
http://linked.open...dnocenehoVysledku	539079
http://linked.open...ai/riv/idVysledku	RIV/00216224:14110/05:00035910
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	multiple myeloma; autologous stem cell transplantation (en)
http://linked.open.../riv/klicoveSlovo	autologous stem cell transplantation multiple myeloma
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[B145AFCD18B1]
http://linked.open...i/riv/nazevZdroje	Bone Marrow Transplantation
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	8 (xsd:int)
http://linked.open...cetTvurcuVysledku	9 (xsd:int)
http://linked.open...UplatneniVysledku	2005
http://linked.open...v/svazekPeriodika	35
http://linked.open...iv/tvurceVysledku	Adam, Zdeněk Hájek, Roman Krejčí, Marta Mayer, Jiří Pour, Luděk Büchler, Tomáš Vorlíček, Jiří Křivanová, Andrea Svobodník, A.
http://linked.open...ain/vavai/riv/wos	000226245100008
issn	0268-3369
number of pages	6 (xsd:int)
http://localhost/t...ganizacniJednotka	14110

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