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  • Analysis of cerebrospinal fluid (CSF) represents an important role in the diagnosis of multiple sclerosis. Oligoclonal IgG bands ,blood-CSF barrier and cell count are normally examined. Intrathecal synthesis of specific IgG antibodies against measles , rubella and varicella zoster virurses called MRZ reaction is a new diagnostic marker which is present in patients with chronic autoimmune diseases with the involvement of the nervous system , especially multiple sclerosis. The aims of our work were to investigate the frequency of intrathecal synthesis of specific antiviral antibodies and to determine a typical CSF profile in patients with multiple sclerosis.We examined a cohort of 50 patients. The intrathecal synthesis of specific antibodies was evaluated in the form of antibody indices calculated according to Reiberś formula.The condition of blood - CSF barrier was expressed by the ration of albumin in CSF and serum. Oligoclonal IgG bands were detected by isoelectric focusing .
  • Analysis of cerebrospinal fluid (CSF) represents an important role in the diagnosis of multiple sclerosis. Oligoclonal IgG bands ,blood-CSF barrier and cell count are normally examined. Intrathecal synthesis of specific IgG antibodies against measles , rubella and varicella zoster virurses called MRZ reaction is a new diagnostic marker which is present in patients with chronic autoimmune diseases with the involvement of the nervous system , especially multiple sclerosis. The aims of our work were to investigate the frequency of intrathecal synthesis of specific antiviral antibodies and to determine a typical CSF profile in patients with multiple sclerosis.We examined a cohort of 50 patients. The intrathecal synthesis of specific antibodies was evaluated in the form of antibody indices calculated according to Reiberś formula.The condition of blood - CSF barrier was expressed by the ration of albumin in CSF and serum. Oligoclonal IgG bands were detected by isoelectric focusing . (en)
Title
  • The diagnostic significance of intrathecal occurence of selected antiviral antibodies in multiple sclerosis
  • The diagnostic significance of intrathecal occurence of selected antiviral antibodies in multiple sclerosis (en)
skos:prefLabel
  • The diagnostic significance of intrathecal occurence of selected antiviral antibodies in multiple sclerosis
  • The diagnostic significance of intrathecal occurence of selected antiviral antibodies in multiple sclerosis (en)
skos:notation
  • RIV/00216224:14110/05:00014964!RIV10-MSM-14110___
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • Z(MSM0021622404)
http://linked.open...iv/cisloPeriodika
  • 4
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 517851
http://linked.open...ai/riv/idVysledku
  • RIV/00216224:14110/05:00014964
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • Multiple sclerosis; intrathecal synthesis; MRZ reaction; cerebrospinal fluid (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • CZ - Česká republika
http://linked.open...ontrolniKodProRIV
  • [902F8A2ACFFB]
http://linked.open...i/riv/nazevZdroje
  • Scripta Medica
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 78/2005
http://linked.open...iv/tvurceVysledku
  • Krbková, Lenka
  • Štourač, Pavel
  • Bednářová, Jana
http://linked.open...n/vavai/riv/zamer
issn
  • 1211-3395
number of pages
http://localhost/t...ganizacniJednotka
  • 14110
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